Transcript Hemophilia A - Biology Junction

Hemophilia
Genetics of the F8C Gene
F8C Gene
 Hemophilia
is
correlated to
defects in the
F8C gene.
 The F8C gene
is found on the
X chromosome
Inheritance
 Hemophilia
is an X-linked
recessive disorder that affects
one in 10,000 males and very few
females
 Since females have two X
chromosomes, they are often
carriers of the gene
Hemophilia
 Persons
who inherit the F8C gene
lack a clotting factor to prevent
bleeding
 Even simple cuts may be a serious
problem for these people
Famous Pedigree of
Hemophiliacs & Carriers
Queen Victoria
(carrier of hemophilia A)
Daughter #1
(Carrier)
married Russian royalty
recessive gene passed from
Russian czar's family to Germans
Daughter #2
(Carrier)
married Spanish royalty
Russian Royal Family