Transcript MGM Retreat - Advanced IDP Genetics curriculum

IDP-BMS Genetics concentration
[me – Peggy Wallace, PhD]
and
Lei Zhou, PhD
[email protected], 392-3055 (ARB)
[email protected], 273-8169 (CGRC)
UF Dept. of Molecular Genetics and Microbiology
• 35 students (21 mentors)
• 6 students joined last year
Curriculum: The > 6 advanced coursework hours
(after first year): any IDP-approved courses.
Genetics Journal Club each Fall, with choice of
journal club in the spring
First 88 graduates (2001 through 2014):
 ave. 5.4 years
 ave. 1.8 first-author publications
 ave. 2.6 co-authored publications.
31% academia, 17% biotech/pharma,
38% fellows/non-tenure positions,
6% federal agencies, 10% other
Genetics as a project
• Create or collect mutant cells/animals
(spontaneous, vector-directed, induced by
carcinogens). Study vs “wild type”
• Use the reverse to prove a concept or
specificity (complement or rescue).
• Survey or breed populations to test
inheritance, population parameters and
dynamics, genetic mechanisms.
Hypothesis-driven
OR
discovery-based studies
Often can’t predict what you will discover
Genetics as tools in a project
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Vectors (transgene, shRNA, etc)
Animal models
Population nucleic acid samples
Cell models
Studying specific genes
Omics sequence and data (genome,
transcriptome, methylome, epigenome)
• Bioinformatics
wide range of research topics
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gene therapy (create vectors, test models)
mouse genetics (disease models, test mechanisms)
other models (fruit fly, axolotl)
epigenetics (imprinting, chromatin)
structure/function (pheno/geno)
stem cells
cancer genetics
omics and bioinformatics
biomarkers and translational projects
prokaryote genetics
genetics of viral pathogens
population genetics
genetic linkage & association
Conditions Studied
ALS, Pompe Disease, Retinitis Pigmentosa,
Spinocerebral ataxia, neurofibromatosis,
trauma, Angelman’s syndrome, Prader-Willi
syndrome, Huntington’s disease, Usher
syndrome, cardiomyopathy, myotonic
dystrophy, cystic fibrosis, leukemia, Kaposi’s
sarcoma, HSV1 infection, alpha-1 antitrypsin
deficiency, salivary gland tumors, wound
healing, vitiligo, pain, liver cancer, HIV,
cylindromatosis, diabetes, lung cancer,
hemoglobinopathies, Williams syndrome,
supravalvular aortic stenosis.