Transcript No Slide Title

Dr. Stuart Reichler
Bio 325
Date
Subject
Aug 29, 31
Introduction, Philosophy of Science, and Strong Inference
Sept 3
Labor Day (no class)
Sept 5, 7
DNA and Gene Structure
10, 12, 14
Signal Transduction
17, 19, 21, 24
Transcription and Translation (Homework #1 due 9/17)
Sept 26
Exam 1 (from 7:00pm to 8:30pm) (9/26 last day to drop w/o permission)
Sept 28, Oct 1
Gene Expression in Bacteria and Viruses
Oct 3, 5, 8, 10, 12
Gene Expression in Eukaryotes and Development
15, 17
Genome Organization
19, 22, 24, 26
Biotechnology (10/24 last day to Q drop)
Oct 29
Exam 2 (from 7:00pm to 8:30pm)
31
Mitosis and the Cell Cycle
Nov 2, 5, 7
Mutations and Cancer
9, 12
Meiosis and Developing Genetic Diversity
14, 16, 19
Inheritance
Nov 21-23
Thanksgiving (no class)
26, 28
Inheritance
30, Dec 3
Evolution
Dec 5
Exam 3 (from 7:00pm to 8:30pm)
Dec 15 9am-noon
Final Exam
Q: Why does DNA have a very regular 3dimensional shape while RNA has a
varied 3-D shape?
Q: Why does DNA have a very regular 3dimensional shape while RNA has a
varied 3-D shape?
A: RNA is single-stranded so areas with
complementary bases form loops and bend
the RNA. DNA is double stranded, and the
regularity of its structure only allows one 3D structure, a double helix.
Q: Describe two problems that would
prevent a human gene from being
properly expressed in bacteria.
Q: Describe two problems that would
prevent a human gene from being
properly expressed in bacteria.
A: Eukaryotic promoters do not work in
bacteria, eukaryotic promoters need
transcription factors. Eukaryotic genes
typically have introns, and bacteria cannot
splice out introns.
Studying Biology:
•Start with a question.
–For example:
How? Why? When? Where? Etc?
•How do we get answers?
–Strong Inference presents one method
(article on webpage)
What causes Mad Cow Disease (aka BSE)?
Brain tissue from cow with BSE. Scrapie in
sheep, CJD or Kuru in humans looks similar.
How could you test for the infectious agent?
Dr. Stanley Prusiner
was awarded the
Nobel Prize in 1997
for the discovery of
prions… infectious
proteins.
normally folded proteins
Prion
(abnormally
folded
protein)
Prion
Propogation
Interaction
between prion
and normal
protein causes
normal protein
to misfold…
… which leads to
increasing numbers
of prions
Studying Biology:
•Start with a question.
–For example:
How? Why? When? Where? Etc?
•How do we get answers?
–Strong Inference presents one method
(article on webpage)