Transcript genetic_mystery

Romanovs and
Revolution
A Genetic History Mystery
The Romanovs
Tsar Nicholas II
Alexandra
Tatiana
Marie
Alexei
Anastasia
Olga
The Romanov
children
Tsarevich Alexei
Grigory Rasputin
Hemophilia
•Caused by a single, recessive allele.
•This allele codes for a blood-clotting
protein. If the protein is defective, then
the blood does not clot properly.
•Untreated, victims often die in
childhood or teen years, rarely live to
adulthood.
The Windsor Pedigree
This pedigree shows who had hemophilia in the Windsor
family line. Why only males? And who are the carriers?
The Completed Pedigree
Notice only women can be carriers. Why?
And here’s the real mystery:
Why are there no carriers before Victoria?