Transcript Pedigree - phsgirard.org

Pedigree
Model depicting how a trait
moves through a family
“Modes of Inheritance”
Chromosome Types
• Autosome – Any non sex chromosome (1-22)
• Sex Chromosome – The X or Y chromosome
Pedigree
Basics
Autosomal Recessive
What to look for:
Non-affected parents
have affected
children
Trait “skips” a
generation
Autosomal Recessive Diseases
• Cystic Fibrosis
• Tay Sachs
• Sickle Cell Anemia
• Lethal gene affects early in life
Lethal gene activated after child rearing years
ALS also autosomal dominant
Sex Linked Traits
• Color Blindness
• Hemophilia
• Duchenne Muscular Dystrophy
Sex linked – unaffected moms with affected sons