Transcript Pedigree analysis: determining the pattern of inheritance

Pedigree analysis: determining
the pattern of inheritance
Human Pedigrees
• The use of pedigrees is an important method
for analyzing the inheritance of traits in
human populations
Patterns of Inheritance
• Six basic patterns
– Autosomal dominant
– Autosomal recessive
– X-linked dominant
– X-linked recessive
– Y-linked
– Mitochondrial inheritance
New Computer Software can be used
to Prepare Pedigrees
Keep In Mind
• Pedigree construction and analysis are basic
methods in human genetics
A Rare Autosomal Recessive Trait
Some Autosomal Recessive Traits
Pedigree: An Autosomal Dominant
Trait
Some Autosomal Dominant Traits
Example of an Autosomal Dominant
Trait
• Marfan syndrome
– Affects the skeletal system,
cardiovascular system, and eyes
– Individuals are tall, thin, long arms
and legs–thin fingers
– Heart defects
Cardiovascular Effects
of Marfan Syndrome
Aorta
Vena cava
Pulmonary
artery
Right
auricle
Left
ventricle
Right
ventricle
Cardiovascular Effects
of Marfan Syndrome
Aorta
Right
auricle
Area of aorta
affected in
Marfan
syndrome
Left ventricle
Right
ventricle