Transcript designed - Center for Genomic Pathology

Genomic Pathology:
One Gene, One Disease, One Medicine
Robert D. Cardiff, M.D., Ph.D.
Director
Center for Genomic Pathology
Center for Comparative Medicine
Department of Pathology and Laboratory Medicine
University of California, Davis
http://ctrgenpath.org
ras
myc
neu
Gene-Specific Breast Cancer Phenotypes
GEM PROSTATE TUMORS
That Mimic Human
A
B
Induced by
MYC
SPONTANEOUS
HUMAN
WHICH IS HUMAN?
A or B?
Elwood-Yen PMID 14522256
Genomic Medicine
1.
The human genome is sequenced
The genetic code has been “broken”
2.
3.
The function of each gene will be
determined by phenotyping
(Phenogenomics)
The phenotypes will be ‘induced’ in
Genetically Engineered Mice (GEM)
The mouse is a powerful model for
human genomics



Genomics will revolutionize medicine.
Mouse mutants provide the most
durable and high throughput means
of understanding human genomic
biology.
Mouse models represent the virtual
“Koch’s Postulates” of modern
biology.
What is Genomic Pathology?




The genome has been sequenced.
The function of each gene needs to be elucidated by
phenotyping.
(Phenogenomics)
Genes are associated with diseases. Diseases require
microscopic validation.
(Genomic Pathology)
Gene phenotyping starts with the mouse, analyzed by
Genomic Pathologists.
Far too many devastating, costly errors in the literature!
The Impending Crisis



Industry, NIH and other international
agencies are generating huge
numbers of genetically modified mice.
(20,000 -200,000 new strains)
Mouse mutant phenotypes are often
inadequately characterized or
misinterpreted.
Not enough existing comparative
pathologists to meet this need.
Documenting the critical shortage
The PRIME and ACVP reports
– Few experimental mouse
pathologists
– Few experienced with multiple
mouse lines.
– Necropsies often done without
benefit of trained pathologists.
– Workers often lack appropriate
qualifications.
The Solution:

A coordinated system to share information and
access available comparative pathology resources.

A world-class faculty

Streamlined interactive training of future generations
of comparative pathologists.

Proper training of all levels of “parapathologists”.

Economical Web-based training programs

Proper certification of Trainees.
How do I Learn about
Genomic Pathology?
http://ctrgenpath.net
“GENOMIC PATHOLOGY”
Divisions of Course Work
offered over the Internet

LEVEL ONE: BIOLOGY OF LABORATORY MICE
– DESIGNED For graduate students, fellows and technical staff
– GOAL: To train the student to more effectively and accurately
perform studies using a mouse model. Emphasis on identification of
gross and microscopic features of the healthy and diseased animals

LEVEL TWO: PATHOLOGY OF GENETIC ENGINEERED MICE
(GEM)
– DESIGNED For persons with advanced degrees and Level I graduates
– GOAL: To provide training in the biology and pathology of GEM for
PIs.

LEVEL THREE: ADVANCED STUDIES OF GEM
– DESIGNED For certified veterinary and medical pathologists
who desire advanced study on GEM
– GOAL: To provide graduate information on specific pathologic
changes seen in many GEM strains. To prepare the pathologist to
become competent in evaluating these unique changes both gross and
microscopically.
CGP Faculty









James M. Crawford, M.D., Ph.D. Chairman of Pathology and
Editor in Chief Lab Investigation (229 PubMed
publications)
Stephen W. Barthold, D.V.M.. Ph.D. Professor and Director,
Member NAS (211 PubMed publications), Co-author Percy
and Barthold “Rodent Pathology”.
Rod Bronson, D.V.M. (471 PubMed publications)
Robert D. Cardiff, M.D., Ph.D., Distinguished Professor,
Former Chair of UCD Pathology, Former UCD Director of
Medical Informatics AAAS Fellow (234 PubMed
publications)
Murray B. Gardner, M.D., Professor Emeritus, Former Chair
UCD Pathology. AAAS Fellow (245 PubMed publications)
VE Ted Valli, D.V.M., M.Sc., Ph.D. Former Chair of
Pathology, Guelph, Former Dean Illinois College of
Veterinary Medicine (225 PubMed publications)
Jerrold M. Ward, D.V.M., Ph.D. (566 PubMed publications)
Robert R. Maronpot, D.V.M. (273 PubMed publications)
See http://ctrgenpath.net for all CGP members
LEVEL ONE
60+ Hours of PPT
http://ctrgenpath.net