Transcript Animal Models in Immunology - Academic Resources at Missouri

Animal Models in Immunology
Adam Brown and Teresa Fulk
Nude Mouse
• Discovered in 1962.
• Is hairless, and more importantly, lacks
a thymus.
• Homozygous for recessive trait called
“nu”
• Immunodeficient since it can’t produce
T-cells and lymphocytes.
• This allows for implantation of human
tumor cells into mouse without
rejection.
Scid Mouse
• Def. “A laboratory animal that,
lacking an enzyme necessary
to fashion an immune system
of its own, can be turned into a
model of the human immune
system when injected with
human cells or tissues.”
• Discovered in 1983.
• S.C.I.D. – Severe combined immune deficiency
• Found to be more immunodeficient than nude
mice
• Used as a blank slate immune system.
• Used in oncology, immunology, infectious
disease, rejection of tissue transplants.
Transgenic or Knock-out Mouse
• Mouse that has DNA
artificially transmitted
into it.
• Are produced from
genetically
engineered embryos.
• Through breeding,
strains of mice
created with desired
traits.
References
• http://www.immunecentral.com/immunesystem/iss29.cfm
• http://www.vetmed.ucdavis.edu/Animal_Alternati
ves/cancer.htm
• http://home.comcast.net/~john.kimball1/BiologyP
ages/N/NudeMouse.html
• http://darwin.bio.uci.edu/~tjf/tmf_tgms.html
• http://www.uac.arizona.edu/VSC443/rodentmode
ls/rodentmodel06.html
• http://www.accessexcellence.org/RC/VL/GG/tran
sgenic.html