Transcript Mouse Exercise Monitoring System - Research

Mouse Exercise
Monitoring System
Erik Lappinen, Brooks Alford,
Elizabeth Smith, Matt Gallegly
Advisors: Dr. Michael McDonald, Dr. Randall Reiserer
Vanderbilt University
Department of Biomedical Engineering
Objectives
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Project Description
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Background
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Requirements
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Hardware
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Software
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Timeline
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Budget
Project Description
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Large scale monitoring
system for mice involved
in pharmacological studies
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Display and record data
from exercise wheel
motion
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Possible to monitor up to
100 cages simultaneously
Project Background
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Exercise wheels provide wealth of information
about mouse behavior and physiological changes
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Mouse testing accounts
for 85-90% of all testing
done in pharmaceuticals
$400,000,000
development cost per drug
in the U.S.
Project Requirements
Required:
Wish List:
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Monitor speed and
distance
Identify individual
mice
Real-time
Store data for future
analysis
“Mouse Proof”
Monitor directionality
of exercise wheel
 Addition of visual
graphs of velocity and
distance
Hardware
•Matched IR LED light source/photosensor pair
•Reflective surface placed on small portion of back side of
mouse wheel surface
Hardware
Signal from Sensors
Sensor 1
Response for
forward motion
Sensor 2
Sensor 1
Response for
reverse motion
Sensor 2
Software
•Build off of existing LabView VI
•Continuously retrieves data from two digital input channels per
cage
Software
•Digital Logic Gates
•Count Time between leading
edges to measure RPM
•Clears after 5 seconds of
inactivity
Timeline
 April
13 - Working Prototype
 April
20 - Continue Testing
 April
27 - Final Presentation
Budget
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IR LED's: 100 @ $0.37
IR Detectors: 200 @ $0.28
CPU: 1 @ $936.00
Digital I/O Cards: 1 @ $145, 2 @ $391.50
Connector block/cable kit: 1 @ $63
Supplies for chassis (wood): ~$250
Wires, cables, etc: ~$100
Texts: 1 @ $70
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TOTAL: ~ $1900