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Role of Bioinformatics
in the Genomic Era
Limsoon Wong
Kent Ridge Digital Labs
Singapore
Show & Tell
What are the Themes of
Bioinformatics?
Bioinformatics =
Data Mgmt + Knowledge Discovery
Data Mgmt =
Integration + Transformation + Cleansing
Knowledge Discovery =
Statistics + Algorithms + Databases
Show & Tell
What are the Benefits of
Bioinformatics?
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To the patient:
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To the pharma:
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Save time, save cost, make more $
To the scientist:
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Show & Tell
Better drug, better treatment
Better science
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Prediction
Show & Tell
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Prediction Results
Show & Tell
Medical Record Analysis
age
49
64
58
58
58

chol
266
211
283
284
224
ecg
Hyp
Norm
Hyp
Hyp
Abn
heart
171
144
162
160
173
Looking for patterns that are

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
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Show & Tell
sex
M
M
F
M
M
valid
novel
useful
understandable
sick
N
N
N
Y
Y
Medical Record Analysis
Results
 DeEPs, the “emerging pattern’’ method
 Beats C4.5, CBA, LB, NB, TAN in 21 out
of 32 UCI benchmarks
 Works for gene expressions
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ALL vs AML:
 DeEPS (1 gene) - 0/38 & 3/34
Slonim (50 genes) - 2/38 & 5/34
Colon:
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Show & Tell
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DeEPS (35 genes) - 4/62
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Alon (1000 genes) - 6/62
Genome-Enabled Fruits
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A lot of genes & proteins that are
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candidate diagnosis indicators
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candidate prognosis indicators
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candidate drug targets
What’s Next?
Show & Tell
Evaluate & Choose the
Better Candidates
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Easier to access

Uncomplicated to
modulate
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Clear path to $

Has experience
To do that, you will need
to have ….
Show & Tell
A Molecular Connections
Database consisting of...
DISEASES
INTERACTIONS
PATENTS
EXPRESSION
MUTATIONS
RELATED
MOLECULES
STRUCTURE
Show & Tell
Thank You
Show & Tell