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Role of Bioinformatics
in the Genomic Era
Limsoon Wong
Kent Ridge Digital Labs
Singapore
Show & Tell
What are the Themes of
Bioinformatics?
Bioinformatics =
Data Mgmt + Knowledge Discovery
Data Mgmt =
Integration + Transformation + Cleansing
Knowledge Discovery =
Statistics + Algorithms + Databases
Show & Tell
What are the Benefits of
Bioinformatics?
To the patient:
To the pharma:
Save time, save cost, make more $
To the scientist:
Show & Tell
Better drug, better treatment
Better science
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Prediction
Show & Tell
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Prediction Results
Show & Tell
Medical Record Analysis
age
49
64
58
58
58
chol
266
211
283
284
224
ecg
Hyp
Norm
Hyp
Hyp
Abn
heart
171
144
162
160
173
Looking for patterns that are
Show & Tell
sex
M
M
F
M
M
valid
novel
useful
understandable
sick
N
N
N
Y
Y
Medical Record Analysis
Results
DeEPs, the “emerging pattern’’ method
Beats C4.5, CBA, LB, NB, TAN in 21 out
of 32 UCI benchmarks
Works for gene expressions
ALL vs AML:
DeEPS (1 gene) - 0/38 & 3/34
Slonim (50 genes) - 2/38 & 5/34
Colon:
Show & Tell
DeEPS (35 genes) - 4/62
Alon (1000 genes) - 6/62
Genome-Enabled Fruits
A lot of genes & proteins that are
candidate diagnosis indicators
candidate prognosis indicators
candidate drug targets
What’s Next?
Show & Tell
Evaluate & Choose the
Better Candidates
Easier to access
Uncomplicated to
modulate
Clear path to $
Has experience
To do that, you will need
to have ….
Show & Tell
A Molecular Connections
Database consisting of...
DISEASES
INTERACTIONS
PATENTS
EXPRESSION
MUTATIONS
RELATED
MOLECULES
STRUCTURE
Show & Tell
Thank You
Show & Tell