Transcript Nutrigenomics

Nutrigenomics
KNH 413
Nutrigenomics and Disease
 Cancer
 Use of omega-3 & EPA for rare types
 Predicting benefit difficult in other types
 Responders and non-responders
 Colon cancer
 Folate intake and alcohol
 Fruits and vegetables
 Breast cancer
 Antioxidants
Nutrigenomics and Disease
 Obesity
 Susceptibility with conducive environment
 Polygenic trait
 Promising research
 Perilipin
 Serotonin receptor gene promoter
Nutrigenomics and Disease
 Thrifty Gene hypothesis
 Metabolic status and fetal adaptation predict disease in
adulthood
 Proneness to metabolic syndrome, obesity, diabetes, CVD
Nutrigenomics and Disease
 Diabetes
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Focus on type 2
Metabolic syndrome, insulin resistance
GLUT 2
PPARy
APOE
Nutrigenomics and Disease
 Cardiovascular Disease
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Dyslipidemias
Familial hypercholesterolemia
PUFAs on HDL
Omega-3s and TG
Omega-6s and inflammation
Dietetics and Genetics
 Understanding nutrient interactions and genes
 Future of diet counseling
 Beware of home testing kits
 “DNA diet”
 Sciona
 Costly
 EGAPP Project
 To establish a coordinated process
 Evaluation of genomic applications and
practice/preventionq