Transcript The Preventive Role of Nutrition for BRCA1/2 Mutation Carriers

The Preventive Role of Nutrition
for BRCA1/2 Mutation Carriers
Sharon Bar-Gil, Ph.D., RH (AHG)
Functional Medicine
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Goal: optimal function
Integrative
Science based
For prevention and treatment
Patient centered - focusing on the individual and
tailoring a unique plan to restore balance
• Tools: nutrition, herbs, supplements and life style
modifications
Objective
Understand the Role of Nutrition in
Cancer Prevention.
You’re not ill yet, Mrs. Smith,
but you’ve got potential.”
Nutrition is an Essential Tool in Your
“Cancer Prevention Tool Kit”.
• Nutritional interventions can:
– Reduce & prevent further mutations
– Support proper cell growth and death
Agenda
• Nutrigenomics – nutrition can change
gene expression
• Natural agents that can help regulate
BRCA1/2 genes:
– Fatty acids
– Green tea
– Turmeric
What is Food?
Nutrigenomics –
You can turn genes “On” or “Off”
• Nutrigenomics is the study of how foods
interact with your genes and alter their
expression.
• Genes do not function in isolation.
• They interact with each other as well as
with their environment.
• Nutrigenomics provides the ambitious goal
of optimizing an individual’s health via
nutritional interventions. FASEB; Mutch et al. 19
(12): 1602. (2005)
Nutrition Can Change
Gene Expression
• Animals fed healthy or nutrients deficient diet.
• Those on deficient diet developed colon cancer
within 1 year.
• 2,000+ genes altered their expression toward
a cancer profile
• Pattern of gene expression reverted toward a
healthy profile when nutrients added back to
diet.
Augenlicht LH: Nutritional genomics and
proteomics in cancer prevention conference.
J. Nutr. 133: 2410S–2416S, 2003
Agenda
• Nutrigenomics – How Nutrition can
change gene expression
• Natural agents that can help regulate
BRCA1/2 genes:
– Fatty acids
– Green tea
– Turmeric
Fatty Acids Regulate BRCA1/2
• Fatty acids (such as fish oils) can regulate
BRCA1/2 expression:
– Omega 3 (EPA & DHA) fatty acids have been shown to
reduce pathological cell growth.
– Omega 6 fatty acids have been found to induce tumor
proliferation.
• DHA supplementation significantly reduced the
incidence of tumors (30%) and led to a 60%
increase BRCA1 protein level.
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Bernard-Gallon et-al, British Journal of Nutrition (2002), 87, 281–289
MARIE-LISE JOURDAN, ET-AL ,ONCOLOGY REPORTS 17: 713-719, 2007
Where Are They Found?
• Omega 3 – cold water fish, flax seed, dark
leafy greens, nuts and seeds, olive oil, grass fed
beef
• Omega 6 - Safflower oil, Sunflower oil, Corn oil
Sesame oil, Soybean oil, Walnut oil, commercially
raised beef
Green Tea & Gene Expression
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Helps DNA repair
Inhibits promoting genes (MMP-2, MMP-9)
Increases inhibitory genes
Induces apoptosis
Prevention dosage:
– 300-600 mg (>50% EGCG)=
2-4 caps. daily
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Katiyar, S.K., et al, 1992. Green Tea in Chemoprevention of Cancer.
Adhami, et al, J. Nutr, 2003
Tang et al. Int J Cancer, 2007
Lozano, et al, Febs J, 2006
Susan McCarthy, et-al, molecular Oncology, Volume 1, Issue 2, Pages
196-204 (September 2007)
Green Tea Extract Inhibits PC in
Human Clinical Trial
• 60 volunteers with PC.
• Consumed 200 mg * 3 per day or
placebo for 1 year
• At 1 year: 1 tumor was diagnosed in the
green tea group (3%), while 9 cancers
were found in the placebo (30%)
• S. Bettuzzi, et-al, Cancer
Research 66, 1234-1240,
January 2006
Turmeric –
Synergy with Chemotherapy
• Turmeric has many mechanisms through which it
prevents/destroys cancer cells:
– Inhibit the proliferation of tumor cells
– Destroy mutated cancer cells
• M.D. Anderson Cancer Center (2008) : Mice injected
with aggressive breast cancer cells.
– Divided to 4 groups:
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No treatment = 95% metastasis
Taxol only = 75% metastasis
Curcumin only = 50% metastasis
Curcumin + Taxol = 22% metastasis
• Research dosage= 8 g’ daily
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journal Clinical Cancer Research, October 15th, 2005
M.D. Anderson Cancer Center, Sept. 2008
Prevention = The Concept
of Total Load
• Most of us are exposed to constant low level of toxins.
• Such exposure is not well studied:
– Difficult to measure
– Biochemical individuality = different risks
– Multiple sources of exposures have synergistic
effects
• The ability to inhibit or repair mutations
depends, to a great extent, on lifestyle choices
• The concept of total load =
– Decrease exposure
– Increase protection
Talk to Your Genes With Food
• Drink about 1 glass of red wine 3-5 days a week.
• Limit sugar intake
• Consume moderate amounts of fish, eggs, poultry
and/or wild meats up.
• Limited consumption of red meat
• Eat organically grown or wild foods.
• Spice it Up: Use herbs & kitchen spices liberally
Talk to Your Genes With Food
• Consume mostly food from plant
sources, including fruits, vegetables,
whole grains, beans, nuts, and seeds
• Aim for 2-3 fruits & 5+ vegetables daily
• Eat minimally processed and mostly
seasonally fresh foods.
• Eat a Rainbow: Choose deeply colored
produce and eat full rainbow of colors
daily.
You can be in control when it
comes to actively maintaining
your nutritional status.
Thank You
Sharon Bar-Gil
Ph.D., R.H. (AHG)
www.sharonbargil.com
E-mail:
[email protected]
Tel: 054-818-7275