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Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Areas of basic research that need informatics: • Genomics • Transcriptional analysis • Proteomics • Tissue engineering • Biomaterials Linked to clinical research on patients Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry •Genomics •Transcriptional analysis •Proteomics •Tissue engineering •Biomaterials •High throughput methods that generate huge data sets • Must be integrated via INFORMATICS Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Genomics • • Human genome is the ‘raw material’ Genome-wide scans, SNPs, haplotypes may: – – Predict disease susceptibility (LJP, severe/refractory periodontitis, caries, Sjogren’s, TMD, etc.) Pharmacogenomics- how individuals respond to a given therapy But must also be integrated with genomics of oral microorganisms! Define bacterial virulence factors, etc. Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Transcriptional analysis—what genes are actually expressed? • Gene arrays, SAGE • Normal vs diseased tissues • Subset patients • As above, corresponding studies of genes that pathogens express in vivo (IVET) Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Proteomics • Protein arrays, two-hybrid systems, mass spectrometry If there are 30,000 genes, there may be 1,000,000 proteins!! • Alternative splicing • Post-translational modifications--glycosylation, phosphorylation, myristylation • What proteins interact? • Which predict (early) disease? Response to therapy? Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Tissue engineering What is the time-dependent biochemical and cellular cascade that occurs as a function of: – Implant Material – – – – Surface Texture Microporosity Pore size, density, connectivity 3D dimensional configuration Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Tissue Engineering What is the time-dependent biochemical and cellular cascade …. • Measured in real time, in vivo • How is it affected by “primordial soup”? – Time – Dosage Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Biomaterials/Bioengineering Where along the spectrum of flat polished materials to 10-year clinical invivo study accurately predicts clinical performance – especially of new materials? ???? Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Biomaterials/Bioengineering How can we capitalize on informatics methods/decision theory to improve quality and consistency in clinical procedures? – e.g., color matching of tooth-cementcrown (before the impression is taken and the crown is made) Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry • We NEED to find some way to facilitate efficient communication across disciplines Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry What experiments – or experimental design do we need to facilitate: • Establishing appropriate models • Determining main and interactive effects of multiple variables Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Informatics is the integrative function that interrelates and explores these relationships Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Informatics- and Collaborative Research – NEED YOUR HELP!! Within school …. • Multi-discipline effort needs multi-discipline recognition – Multiple authors – many of which need recognition as major authors, despite the fact that they are not listed first or last – Multiple investigators on major grants – all of whom contribute and are critical to success • e.g., Program project – both overall PI and project PI’s need recognition Dental Informatics and Dental Research: Making the Connection Basic Research in Dentistry Informatics- and Collaborative Research – NEED YOUR HELP!! Within grant review panels …. • New teams are new teams – Probably have not published together – But can’t begin working on interdisciplinary projects easily without any funding