Transcript Mutationsx
Where do mutations occur?
Which mutations are significant for future
generations?
How are mutations connected to the theory
of Evolution?
Where do mutations occur?
Read LE 4 (page 41-42) Traits & Fates;
Do TASK #1-3 using the Pink Sheet with
mRNA sequences of
Normal Hemoglobin (A)
Sickle Hemoglobin (S)
Use the decoding / codon sheet or p.42 chart
to determine the amin0 acid sequence
Answer the analysis questions #1 -5 in
notebook
Share your answer with table partner
Volunteer(s) to share your answers…
Change in DNA involving
A single nucleotide
A few nucleotides (sequences) within a gene or
chromosome
Large sections of a chromosome
Hemoglobin Molecule involves a single
nucleotide change
DNA
Protein
Trait
Read page 43 and complete TASK in pairs
Each pair will be assigned a group number[1- 7]
Each pair uses a white board to show your error
in the DNA sequence
ALL start with TACCGTCTGAAAGGT
Write this DNA sense strand code in
notebook OR on back of pink sheet!
Transcribe and then Translate to the resulting
protein
Use the Doc Camera to show your work
Describe what your group did…
How it altered the amino acid sequence…
What implications this may have…
Where do these changes occur?
What is the difference between a change in a
sex cell and a body cell mutation?
Which is needed for the variations within a
population for natural selection?
During DNA Replication
Environmental Causes:
Radiation
Chemicals
Most mutations are random and occur in
regions of DNA that do NOT code for
proteins --- Called SILENT MUTATIONS
Harmless
Does not affect the production of a ____________
because it does not change its DNA sequence
Harmful
Changes the production of a ______________ which
causes harm (illness or lethal)
Helpful
Changes the production of a _____________ which
makes the organism more fitted to its environment
Harmless
&/or “silent”
Where does a mutation have to be in order to
be passed on to the next generation?
Sex and Gamete cells
Do questions #1-4 (p43-44)
Read the “Living with Gaucher’s Disease”
article and Sandy’s Story and answer
questions #1-5 p46