Transcript 11bHSD1:

11bHSD1:
Why this pesky enzyme is widening
your waistline!
By: Carrie Jones, ND, MPH
Disclosures:

Medical Director of Precision Analytical, Inc.
Copyright 2017: Carrie Jones, ND, MPH
Copyright 2017: Carrie Jones, ND, MPH
What is the (simplified) stress response?
Copyright 2017: Carrie Jones, ND, MPH
11-Beta hydroxysteroid dehydrogenase
Copyright 2017: Carrie Jones, ND, MPH
Where is 11bHSD1 most prevalent?
Copyright 2017: Carrie Jones, ND, MPH
Where is 11bHSD2 most prevalent?
Copyright 2017: Carrie Jones, ND, MPH
It’s a balance, right?
Copyright 2017: Carrie Jones, ND, MPH
This is a fat cell
Copyright 2017: Carrie Jones, ND, MPH
In the fat cell…
Cortisone
11bHSD1
Cortisol
Even when cortisol everywhere
else in the body is ‘in balance’ it
can get amplified in fat cells 
Copyright 2017: Carrie Jones, ND, MPH
The Result?
Copyright 2017: Carrie Jones, ND, MPH
How do I test 11bHSD activity?

Research says you have to look at urinary cortisol and cortisone metabolites

THF (cortisol) to THE (cortisone) ratio
Copyright 2017: Carrie Jones, ND, MPH
Testing:
↑Total cortisol
production/metabolism
Prefers cortisol
systemically due to
11bHSD1
Copyright 2017: Carrie Jones, ND, MPH
Increases 11bHSD1
 Genetics
 Inflammation
 Insulin
 Obesity
itself 
 Thyroid dysfunction
 Licorice supplementation
 Glucocorticoid use
Copyright 2017: Carrie Jones, ND, MPH
Treatment goals!
Copyright 2017: Carrie Jones, ND, MPH
Consider:

Address the inflammation, thyroid, insulin, hormones,
licorice supplementation or medication

Flavonoids

Magnolia

EGCG

Zizyphus vulgaris

Scutellaria baicalensis

Ocinum sanctum

Healthy bile acid
Copyright 2017: Carrie Jones, ND, MPH
Thank you for listening!
Copyright 2017: Carrie Jones, ND, MPH