Transcript dihydrouracil (D)

Translation
Cien años
de soledad
ATGGGGUUUGGC
mRNA
One
hundred
years of
solitude
MGUG
polypeptide
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mRNA
tRNAs
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ribosome
mRNA
many aa codons
cap
TAG
ATG
open reading frame
size usually 500 - 5000 nt
(A)n
tRNA
acceptor arm
about 80 nt
contains unusual bases
pseudouracil ()
dihydrouracil (D)
methyluracil (T)
 loop
D loop
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anticodon
loop
Kenyon College
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Kenyon College
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Thinkquest
Essential Biochemistry
Wiley
charging of tRNAs
amino
acid
aa tRNA synthetase
aminoacyl tRNA
carboxyl group of aa connected to 3’ OH of tRNA
specificity of aa tRNA synthetases
Arg + tRNA
arginyl tRNA
Arg tRNA synthetase
specific for one aa
and its correct tRNAs
many amino acids have more than one tRNA
rRNAs
 half of all RNA in the cell
# of ribosomes very large ( 106 in a large cell)
each mRNA may have several ribosomes on it
(polyribosome = polysome)
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