Transcript Normal Sickle Cell

Components of Blood
• Whole blood
– RBCs
– WBCs
– Platelets: cell fragments that aid in clotting
• Plasma
– 90% water (allows materials to dissolve)
– Amino acids, glucose, hormones, vitamins, salts, waste
– Concentrations allows diffusion in/out of blood stream
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Red Blood Cells
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Produced from stem cells in bone marrow
Lose nucleus as they mature
Transport O2 to cells; remove CO2
O2 binds to hemoglobin proteins
Dead cells filtered by liver & spleen
Sickle Cell
Normal
ABO Blood Groups
• Proteins on blood cells determined blood type
• Antigen (markers)
– proteins on cell’s surface that identify cells as foreign or
natural
• Antibodies:
– proteins from WBCs to attack invaders
– Float freely in plasma
Group A blood
• A antigens on the
surface of your RBCs
• B antibodies in your
blood plasma
Group B blood
• B antigens on the
surface of your RBCs
• A antibodies in your
blood plasma
Group AB blood
• A and B antigens on the
surface of your RBCs
• no A or B antibodies at
all in your blood plasma
Group O blood
• No A or B antigens on
the surface of your
RBCs
• both A and B antibodies
in your blood plasma
Rh Factors
• Rh+
– Protein found in
blood
– Can receive Rh+ or
Rh- blood
• Rh– Lack protein in
blood
– Only receive Rhblood
1) Can this work?
• Acceptor
• Donor
O-
AB-
2) Can this work?
• Acceptor
• Donor
A+
A-
3) Can this work?
• Acceptor
• Donor
AB-
B-
1) Can this work?
• Acceptor
• Donor
O-
AB-
2) Can this work?
• Acceptor
• Donor
A+
A-
3) Can this work?
• Acceptor
• Donor
AB-
B-
White Blood
Cells
• Remove foreign
invaders & dead
cells
• Able to move
through body
tissue
Platelets
• Form clots when
bleeding
• Proteins form a web
to trap cells &
platelets