Transcript Post-weaning diarrhea

POST-WEANING
DIARRHEA
Diagnosis,Treatment,And Prevention
Dr.Nathan Winkelman
2003.6. 9
명품D&F
김 종 운(018-419-4409)
Nursery(이유)
• Soybeem
• Post -weaning Diarrhea:E.coli.k88.F18
• PRRS related nursed problems :Strep
suis ,Respiratory Diease,mortality(폐사)
• Hemophilus parsuis,Strep suis,occasionally
Actinoballus suis(글레서,연쇄상,흉막)
• Emerging disease-Circovirus Type A
이유자돈 전신성 소모성 증후군 (PMWS)
Postweaning multisystemic wasting syndrome
• 97~98년 부터 증폭되는 신종 질병
- Porcine circovirus
- 이유자돈말기부터 육성초기까지 뚜렷한 증상
없이 성장 지연 (5~15% 돈군)
- 이유자돈중 노란 위축돈 (간장손상-황달)
- 위궤양과 빈혈
- 서해임파절의 발적/괴사,신장점상출혈,피부발적
• PRRS로 오진 가능성 (백신 효과 없음)
• 6개월 후 자연 소진 사례 (현재로서는 무대책)
글레서씨병 Hemopholus Parasuis
• 한국의 발병빈도가 높고 균분리가 매우 곤란:
- 외국과 달리 PRDC 1차 병원체로 간주
• 3년 미만의 신돈사에서도 자주 발생
• 이유자돈중 10%의 산발적 고질적 위축
- 수직감염: 모돈에 백신
- 수직감염: 포유자돈/이유자돈초기에 백신
• PRRS와 상관관계가 높은 듯
- 병행진단의 필요성
Enteric Pathogens in the Nursery
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E,coli
Rotavirus
TGE
Salmonella typhimurium
Coccidiosis
Non-infectious
– Stress
– Nutritional
High Performance Nursery
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Mortality
< 1.5%
Age
70days
Weight
70-77lbs(31.5-34.65kg)
ADG
1.05-1.15lbs(470-517g)
F/E
1.4-1.7
Feed Cost/ # gain
Feed Cost/Pig to 70#
Health technologies to reduce
or Eliminate Diease(제거)
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Complate depopulation and repopulation
Partial depopulation and repopulation
Isowean Principle
Test and Remove
All in ,All out
– by site ,locus ,building, or room
Diease Eliminated Through
Isowean Principle
Diease
Maximun weaning age
• Strep suis 연쇄상구균
none
• PRRS
none
• Hemophilus Parasuis
< 10days
• Mycoplasma
<14days
• APP
<14days
• Toxigenic Pasteutella Multocida<14days
• Bodetella Bronchiseptica
<14days
Diarrhea-nursery pigs
Post-Weaning Enteric Pathogens
Agent (원인균)
Comment
E.coli-colibacillosis
Very common
E,coli -edema diease
Uncommon
E.coli -septicema(패혈증)
Emerging diease
Salmonnella
Septicema or Diarrhea
Rotavirus
Concurrent with e.coli(대장균동시작용)
TGE
Edemic -very common
Epizootic-Winter
coccidiosis
more common with early weaning
nutritional
very common
B-Hemolytic E. coli
• Diarrhea, Edema Diease and
Septicemia in weaned pigs.
USA WEANING AGE
• 16-18days
Treatment Routes For Diease
• Injetable Antibiotics sentive to the pathogen
are the most cost effective method of
treatment
• Water medication is implement when 520%of the population is clinically affected.
Pigs continue to drink even when they are
not eating(임상적감염5-20%시)
• Feed medication least effective methed of
treatment
Diarrhea Treatment
Based on Sensitive Test Results
• Injectable
– Gentamaycin-Dos :6.6mg/kg bw for 2-3days
– Ceftifur(excene17)Naxcell-Dose:1cc/10kg
for3days
– Ampicillen-Dose:2.3mg/kg
– Amicacin-Dose:6.6mg/kg
– Spectinomycin-Dose :1cc/10kg B.I.D
E.coli Water Medication
• Gentamation Sulfate- 0.5mg/lbday for 3day
• Trimethoprin(5mg per ml)and
Sulfamethoxazole(40mg per ml)-2 pints per
128 gallon stock solution
• Neomycin 325 Power-22mg/kg for 7+day
• Amoxicillin-Extra lable use
• Cephlexin-Extra lable use
E.coli Treatment Feed
Antibiotics
• Denegard/Aureomycin at 35g/ton
Tialimulin and 400g/ton Chlortetracline
commonly used in start pellets.(부스팅1호)
• Corbodox most popular for enteric
diease ,however ASP-250 is broader
sprectrum for both respiratory and enterics
Hemolitic E.coli-Diagnosis
• Clinical sign:임상소견
– Diarrhea-3 days to 3week post-weaning
– Gaunt, Rough-haired(수척,털이거침)
• Moibidity-1-40%(이환율)
• Motality-1-20%(패사율)
• Ante-mortem:Rectal swabs-Culture,PCR
Feed Antibiotic FDA approved
for Bacterial Enteritis
(Salmonnella,E.coli)
Antibiotic Approved level
Chlortetracycline 100-200
Oxitetracycline
50-100
ASP
250g/ton
Virginiamycin
25g/ton
Bacitracin
250g/ton
Withdrawal
0
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15days
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Prevention
• Acidity and Chlorinate the water for 3-7days
after arrival.
– 1.Citric acid : 1-2 /128 gallons
– 2.Electrolytes:Organic acids ,Glycine
– 3.Chlorinate- 2-3ppm Chlorine
Optimum PH gut levels for
pathogen growth
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E.coli
Streptococci
Salmonella
Stapirococci
Clostridia
Pseudomonas
6-8
6-7.6
6-7.5
6.8-7.5
6-7.5
6.6-7.0
• If PH is 4.0there is no growth of the above
pathogens: Target is to get close PH 3.0 as Possible
Nersery Management
• Attention to details to maximise weaning
weights!
• Hot water wash
• Environment
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warm ,dry, and draft free
integrated heater and fan controls
waterers(10두에1개)
feeders
Feeding Manganment in nersery
• Withhold feed for 6-12hour post weaning
before feeding
• Comfort mat-feed 4-6 times per day
• Limit feed the first 2-5days
Vaccines
• There are no effective commerical E,coli
vaccinations available to control post
weaning diarrhea
• Oral autogenous vaccines vaccines have
shown promise
Nutrition
• Use complex nursery diats with highly
digestable feed ingredient(소화잘되는성분)
사료)
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Spray dried porcine plasma(혈장)
Fresh Menhaden fish meal
Skim milk(탈지분유)
Synthetic amino acids
Optimum vitamin levels
Nutrition
• Diarrhea control
– add zinc oxide at 3,000ppm for 2 week time
period between 15-25pounds
• Remove blood meal
• Reduce Iron
• Specific 4or 5 phase feeding burget programs
Recommend Lysine Levels for
Segregated Early Weaned Pigs
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Diet Pig wt,kg Total,Lysine
Sew
4.9
1.7-1.8
Transition 4.9-6.8 1.5-1.6
Phase2 6.8-11.4 1.35-1.45
Phase3 11.4-22.7 1.25-1.35
DigestibleLysine%
1.4-1.5
1.25-1.35
1.10-1.20
1.05-1.15
Nersery Performance
age
wt(ADG)
1988-Top10% 63days 47 lb(0.8)
1999-Top10% 63days 63 lb (1.1)
1999 Best Herd 63days 72 ld((1.5)
‘99
28.35KG
F/E
1.8
1.5
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1999년BEST HERD
32.4KG
ILEITIS
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가점막(만성)
출혈성혈액-비육돈 말기
콜타르 성 설사
괴사조직(노랗게 물드는 경우 담즙)
층어리짐
• 산발적으로 발생
ILEITIS
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약품
첨가량
Aereomycin 100g/ton
cabadox
25g/ton
Linco
40g/ton
급여
21일
42일
21일
휴약
없슴
42일
없슴
소독
• 소독제 3-4개월 바꾸어 사용
– 페놀-포르말린-암모늄 클로라이드 순환
• 하절기 암모늄 클로라이드 첨가된 소독약
사용