Transcript Animal models17

Study of HIV-2 in monkey
Pigtail macaque
(Macaca nemestrina)
Baboons
(Papio cynocephalus)
- This species are susceptible to infection with some
isolates of HIV-2.
- HIV-2 have been developed that induce AIDS-like
disease and depletion of CD4+ cell.
- Similarities in disease progression and development of
AIDS to human HIV infection.
Study of Simian immunodeficiency virus (SIV)
in non human primate model
-SIV is lentivirus and close related to HIV-1, HIV-2
-It share up to 50% similarity to HIV-1 in nucleotid level
and share about 88% of amino acid homology to HIV-2