Transcript Document

Amino acid Metabolism 2
C483 Spring 2013
1. Arginine is biosynthesized from this precursor:
A) Pyruvate
B) Oxaloacetate
C) a-ketoglutarate
D) 3-phosphoglycerate
2. A Roundup Ready plant is one that has been genetically modified so that an enzyme
(EPSP synthase) can no longer bind to the active ingredient (glyphosphate) which is a
competitive inhibitor of
A) shikimate (in the aromatic amino acid pathway).
B) tryptophan.
C) lysine.
D) phosphoenolpyruvate (PEP).
3. The conversion of tetrahydrofolate to methylene tetrahydrofolate is coupled to
which amino acid conversion?
A) serine → glycine
B) glutamate → gglycine
C) serine → threonine
D) glycine → alanine
4. If an amino acid is glucogenic, it will not be degraded to ________.
A) pyruvate
B) glutamate
C) fumarate
D) acetoacetate
5. T/F It is possible for an amino acid to be both ketogenic and glucogenic.
Overview of Biosynthesis
• Common intermediates
Recognizing Carbon Chains
• Name these AA precursor molecules, and
match them to the AA that is produced:
alanine, serine, glutamate, asparagine
Essential Amino Acids
• Definition of
“essential”
• Ambiguity with
cysteine and tyrosine
• Arginine is essential
in some mammals
and in some
development stages
Aromatic AA Biosynthesis
Catabolism of carbon chain
Overview of Catabolism
• Ketogenic vs Glucogenic amino acids
• Utilization of branched AA in muscle
• Know particular cases
– Deamination: Ala, Asp, Asn, Glu, Gln
– Glucogenic: Arg
– Ketogenic: Leu
– Both: Ile
– Cofactor synthesis: serine
• Importance of PLP in amino acid processing
Ketogenic and Glucogenic
Answers
1.
2.
3.
4.
5.
C
D
A
D
T