Transcript Detoxification and Cancer

DETOXIFICATION AND CANCER
The role of chelation and detoxification in the treatment and
prevention of cancer
Detoxification
What are you detoxifying & why?
Detoxification Pathways
• Drainage vs. elimination
• Drainage- from the organ/matrix to the circulation
system
• Elimination- From the circulation system out via the GI
Tract, urination, breathing (lungs), skin, & other
excretions
Chelation & Detoxification Principles
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Patient’s Health
Patient’s Disease
Timing - Seasons
Complexity of Toxic State
Detox Philosophy
• Antidote
• Transformation
• Acceptance
• Freedom
Detox Principles & Philosophy
• Understand the difference between drainage and
elimination and how to support both
• Initial preparation - assessment, strategy & planning
with emphasis on seasonal timing
• Utilize appropriate support structure and tools
• Construct realistic goals and proceed slowly
Detox Principles & Philosophy
Follow up program:
• Maximize benefits of detoxification
• Smooth transition after detoxification
Freedom - the concept of loosening our grip:
• Mentally/Emotionally/Spiritually: supports overall
detox
• Physiologically: releasing the toxins from organs &
tissues
• Grasping & letting go
• Expanding while detoxifying
The Detoxification Cycle
• Liver as the starting point
• Follow circulation
• Lungs
• Heart/brain
• Gastrointestinal tract
• Systemic - joints, etc.
• Elimination or… back to the liver or other tissues
Tools in Detoxification
• Diet
• Nutritional supplements
• Botanicals
• Acupuncture & Moxibustion
• Heat therapies - Infra red saunas
• Purging - colonics, enemas, washes
• Intra venous therapies
• Lymph drainage
• Meditation
• Body/Mind Connection
Detoxification Diet
• High fiber
• High greens
• Help elimination - liver & large intestines
• Catabolic
• Organic
• Modify as needed
Heavy Metal Detoxification Principles
• Go slow
• Appropriate timing
• Avoid fasting or radical low protein diets while detoxifying
heavy metals
• Supplement with minerals
• Support the body in the process
• Have a long term maintenance plan
Chelation Guidelines:
A Multi-step Graduated Program
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Start by Chelating from the blood & GI Tract
Once total body burden has decreased, enhance
chelation & add organ specific detoxification
Support drainage, elimination mechanisms &
pathways
Support body’s system
Minimize side effects & aggravations
Gentle & gradual chelation is almost always
preferable
Detoxification Supplements
• Modified Citrus Pectin/Alginate complex
• Medicinal Mushrooms - balanced, multi-nutrient type
formulations
• Alpha Lipoic Acid, sulfured amino acids, others
• Digestive support - herbs, enzymes, probiotics
EDTA, DMSA & DMPS Used for Provocation
• Sometimes called a "challenge" or "provoked" heavy metals
test.
• The ability of EDTA, DMSA or DMPS to mobilize heavy metals
stored in body tissues (& therefore not typically present in the
circulation) increases the excretion of heavy metals in the
urine, leading to more accurate identification of total heavy
metal toxicology than hair or blood tests alone.
• This must be performed by trained medical practitioners, with
timed urine collections sent out to a specialized laboratory for
analysis.
Safe Natural Chelation
Natural Chelators
• More recently natural chelating agents have also been
discovered, such as the use of pectins after the Chernobyl
disaster in 1986.
• Includes polyuronide soluble fibers (Modified Citrus Pectin &
kelp alginates), Vitamin C, natural thiol compounds & sulfur
containing amino acids, kelp derived alginates & even herbs
such as cilantro/coriander (Coriandrum sativum).
• These have properties that bind with metallic ions so that the ion is held by
several chemical bonds. This renders it much less chemically reactive,
producing a complex that is water soluble allowing it to be excreted
harmlessly by the body.
Natural Chelation is Significantly Safer
• Alpha Lipoic Acid (ALA): Rare cases of allergic reaction. Other
possible side effects include headache, muscle cramps, & a feeling of
“pins & needles” in the body. Not to be used in initial state of
chelation.
• Vitamin C: Rare cases of gastrointestinal complaints. These side
effects normally stop as soon as high potency intake is reduced or
stopped.
• Modified Citrus Pectin: No known adverse effects other than
occasional loose stools.
• Alginates: No documented adverse effects
Modified Citrus Pectin (MCP) in Chelation
and Detoxification
• Clinical data indicates that MCP functions as a gentle chelator of
heavy metals.
• The detoxification properties have been confirmed in clinical trials &
case studies.
• MCP has shown in clinical studies to increase the urinary excretion of
toxic metals such as lead, cadmium, arsenic & mercury.
• Long-term use of this gentle safe chelator could effectively reduce
the body burden as shown in a clinical trial.
• The ability of MCP and modified Alginates to remove heavy metals &
environmental toxins on an ongoing basis has been shown to be of
significant clinical benefit in multiple case studies.
Chemical Properties of Alginates & Pectin
Citrus Pectin Chemical Structure
Pectin has neutral sugar chains that branch off from the main
chain of galacturonic acid. Some of the galatcuronic acid groups
have an additional methyl group (CH3-) associated with them.
This is called esterification and it reduces chelation potential.
Esterified
Galacturonic
Acid
CH3
O
O
O
OH
C
OH
C
O
C
O
O
OH
HO
OH
O
OH
C
O
O
O
O
O
OH HO
OH HO
OH HO
OH
OH
Ar
O
O
C
O
O
O
HO
C
O
Rh
OH
O
O
O
HO
OH
OH
C
O
O
O
OH
Neutral Sugars
OH
Galaturonic
Acid Group
C
O
Ar
Rh
Rhamnose
Ar
Ar
Arabinose
O
HO
OH
Alginates have a similar linear structure to pectin without the neutral sugar side branches. Instead
of galacturonic acid, alginate is made up of trepeating blocks of mannuronic and guluronic acid.
A class of complex polysaccharide
compounds known as polyuronides.
Polyuronides are long chains of
repeating sugar acid groups such as
galacturonic acid (pectin) or
mannuronic & guluronic acid
(alginates). Polyuronides are
proven chelators of toxic metals,
pesticides & herbicides, and have
been used in humans exposed to
lead & radioactive metals as well as
in the clean-up of environmental
pollution for over 40 years.
Chelation “Egg Box” Theory
Mechanism of Action
In solution, the long fiber chains stack together
in groups forming pockets where metal cations
can complex with the fiber.
This stacked
formation is sometimes referred to as an "egg
box confirmation".
PCC chain
(comprised of alginate or pectate)
mercury (Hg2+)
lead (Pb2+)
cadmium (Cd2+)
Once the metals are bound to the
fiber they can easily be removed
from the body via the urine or
feces.
Metal Complex Formation
Polyuronides form stacks in solution in
what is known as an “egg box”
structure. Each pocket of the “egg
carton” contains a positively charged
ion to balance the negatively charged
chains. Normally the positive ions are
sodium & potassium. However, toxic
metals especially lead, mercury,
cadmium, & radioactive metals have a
higher affinity for polyuronides than the
essential ions like calcium, magnesium,
& potassium. Toxic metal ions become
trapped in the “egg box” structure &
are eliminated from the body.
Stage I Detoxification
During the first stage of detoxification, avoid
introducing agents that can penetrate into the tissues &
bind heavy metals to them.
The concern is that they can pull heavy metals including
mercury from the circulation into the tissues,
especially the brain.
Stage I Detoxification Continued
• First chelate using MCP, or Modified Citrus Pectin/Alginate
complex to slowly reduce the overall heavy metal burden on
the tissue level for 2-4 weeks.
• During the initial chelation stage, higher dosages of such a
combination are needed.
• For maintenance & long term prevention, lower dosages are
sufficient. Due to ongoing exposure to heavy metals such as
lead & mercury, there is great benefit to using such a
preparation on a long term basis.
• Modified Citrus Pectin/Alginate complex provides on-going
gentle chelation systemically in the blood stream as well as in
the digestive tract.
The Effect of Modified Citrus Pectin on the Urinary
Excretion of Toxic Metals
Eliaz I, Hotchkiss AT, Fishman ML, Rode D.3
Amitabha Medical Clinic & Healing Center, Sebastopol, California, USA. Eastern Regional Research Center,
Agricultural Research Service, U.S. Department of Agriculture, Wyndmoor, PA 19038,3University of California,
Davis, CA, USA. Phytother Res. 2006 20(10):859-64.
• Methods: Prior to oral administration of MCP, the subjects collected
a 24 hour urine sample for baseline measurements. Twenty four
hour urine samples were also collected on day one & day six. The
subjects ingested 15 grams of Modified Citrus Pectin (MCP) each day
for five days & 20 grams on day six. Urine samples were analyzed by
ICP-MS (inductively coupled plasma-mass spectrophotometer).
• Results: Lead, mercury, cadmium & arsenic increased significantly in
urine analysis.
• Essential minerals were not changed significantly.
• No side effects were reported.
Results: Modified Citrus Pectin & Urinary Excretion of Toxic
Elements - Day One
Results – Day One
Urinary Excretion of Elements - Day One
(Percent Change from Day Zero)
#
250
*
% Change from Day Zero
200
p<.05
# p<.1
150
100
#
*
50
*
0
-50
Al
Sb
As
Cd
Element
Pb
Hg
Sn
Results: Modified Citrus Pectin & Urinary Excretion of Toxic
Elements - Day Six
Results – Day Six
Urinary Excretion of Elements - Day Six
(Percent Change from Day Zero)
#
700
% Change from Day Zero
600
*
p<.05
# p<.1
500
400
300
*
200
100
*
#
0
Al
Sb
As
Cd
Element
Pb
Hg
Sn
Results Summary
• In the first 24 hours of MCP administration the urinary excretion of
arsenic increased significantly (30% over baseline/day zero, p<0.05).
• In this same period, the excretion of mercury & cadmium
approached significance (50% & 130% over baseline respectively;
p<0.1). On day six, urinary excretion was significantly increased for
cadmium (50% over baseline, p<0.05) with tin approaching
significance (130% approached significance; p < 0.1).
• In addition, lead showed a dramatic increase in excretion (460% over
baseline) with p=0.05
• No significant changes in the excretion of Al, Ca, Cu, Mg, Zn, Fe, Se,
Pt, Be, Bi, Tl, Th, U & Sb were observed.
• No Side effects were reported.
Modified Citrus Pectin Decreases the Total
Body Burden: A Pilot Human Clinical trial
Eliaz I. Amitabha Medical Clinic & Healing Center, Sebastopol, California, USA.
EcoNugenics, Santa Rosa, California, USA. 228th ACS National Meeting, Philadelphia, PA.
2004.
• Methods: Oral intake 5 g Modified Citrus Pectin/3x day for
4-10 months. Base line body burden and change measured
with DMPS challenge (250mg i.v. followed by 6 hr. urine
collection).
• Results: All subjects showed significant decrease in Mercury
levels. Average decrease was 62.17%, ranging between
38.13% & 74.83% (p=0.0313).
• No significant side effects were noted.
Study Conclusion
Percent Reduction in Mercury
from Baseline
Percent Reduction in Mercury from
Baseline
80%
67.90%
74.80%
72.80%
70%
57.30%
60%
50%
38.10%
• MCP was effective in
decreasing the total
body burden of
Mercury in all subjects.
40%
30%
• MCP is a promising
20%
10%
0%
Patient A Patient B Patient C Patient D Patient E
10 months 4.5 months
4 months 6 months6.5 months
MCP Intervention Individual Results
systemic gentle chelator
of heavy metals that can
be used on an on going
basis.
The Role of Modified Citrus Pectin as an Effective
Chelator of Lead in Children Hospitalized with Toxic
Lead Levels
Zhao ZY, Liang L, Fan X, Yu Z, Hotchkiss AT, Wilk BJ, Eliaz I.
Children’s Hospital, Zhejiang University, School of Medicine, Hangzhou, Republic of China,
Centrax International, Inc, San Francisco, California, USA. Eastern Regional Research
Center, Agricultural Research Services, US Department of Agriculture, Wyndmoor,
Pennsylvania, USA. EcoNugenics, Inc. Santa Rosa, California, USA. Altern Ther Health Med.
2008 14(4):34-8.
Lead in 24 Hour Blood Serum
60
P Value = 0.0016
50
40
30
20
10
0
1
2
3
4
5
6
7
Figure 1 Blood serum lead concentration (ug/dL) measured in blood serum by GFAAS
before (Blue) and after (Red) Modified Citrus Pectin treatment (5 grams three times
daily) in 7 hospitalized children 5-12 years of age. No side effect reported.
Lead in 24 Hour Urine Excretion
140
P Value = 0.0007
120
100
80
60
40
20
0
1
2
3
4
5
6
7
Figure 2 Lead levels (µg/dL) measured in 24-hour urine excretion by GRAS before
(Blue) and after (Yellow) Modified Citrus Pectin treatment (5 grams three times
daily) in 7 hospitalized children 5-12 years of age. No side effects reported.
Stage II Detoxification
Support heavy metal discharge and purge heavy metals
while the body is going through a detoxification process.
We can foster this process by:
• Removal & excretion of heavy metals from the tissue.
• Preventing re-absorption of heavy metals secreted via the bile to
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the gut.
Binding circulating heavy metals, neutralizing & preventing reabsorption in the gut.
Aiding the liver & the detoxifying enzymes in the body, support
drainage & elimination.
Supporting the body’s energy/vitality/strength to allow the body
to “follow through” & successfully chelate the heavy metals.
Supporting tissues where the chelation process can create side
effects, such as the brain.
Stage II Supplementation: Detox Complete
• Poly botanical/thiols/nutrient formula is the second stage in a
unique, two-part integrated detoxification system that
broadens the gentle systemic chelation process.
• Designed as a complimentary formula to be used after 2-4
weeks of gentle chelation with Modified Citrus Pectin/Alginate
complex.
• Poly botanical/thiols/nutrient formula supports detoxification
by addressing multiple facets of chronic heavy metal toxicity.
• It fosters systemic chelation by providing a comprehensive
combination of vitamins, nutrients & herbs that support
detoxification from the tissues & organs and aids in liver
detoxification, promoting elimination through both the
bile/intestines & the urinary tract.
Stage II Supplementation: Detox Complete
Integrative Medicine & the Role of Modified Citrus
Pectin/Alginates in Heavy Metal Chelation &
Detoxification - Five Case Reports
Eliaz, I, Weil, E, Wilk, B.
Amitabha Medical Clinic & Healing Center, Sebastopol, California, USA. EcoNugenics, Santa Rosa,
California, USA.
Forsch Komplementmed. 2007 Dec;14(6):358-64.
Five Case Reports: Results
Percent Decrease in Heavy Metals
Pb = Lead, Hg = Mercury, (Mo) = Months
75% Average Decrease, P Value = 0.026
100%
100%
83%
90%
74%
80%
70%
60%
83%
58%
49%
50%
40%
30%
20%
10%
0%
Pb (3Mo) Pb (6Mo) Hg (6Mo) Hg (6Mo) Hg (6Mo) Hg (12Mo)
Detoxification Guidelines
• Start by Chelating from the blood & GI Tract
• Once Total Body Burden has decreased, enhance chelation &
add organ specific detoxification
• Support drainage, elimination mechanisms & pathways
• Support body’s system
• Minimize side effects & aggravations
• Gentle & gradual chelation is almost always preferable
Detoxification Summary
• Define your goals - patient & practitioner
• Proper timing
• Multi faceted program
• Post detoxification follow up
• Repeat cleanse during spring & fall
• Evaluate success - physical, emotional &
mental/psychological/spiritual
LINKS BETWEEN CANCER AND DENTAL
HEALTH
Specific Dental Risk Factors in Cancer
• Root Canals
• Mercury amalgam fillings
• Infection
• Inflammation
Links between Cancer and Dental Health
• Research shows generalized links between periodontal
disease and certain cancers
• Traditional Chinese Medicine demonstrates
relationships between teeth and organ systems
Relationships between teeth and organs
Periodontal Disease Linked to:
• Cancer
• Systemic Inflammation
• Heart Disease
• Diabetes
• Autoimmune Disease
• Osteoporosis
• Allergies
• Lung Conditions
• Obesity
• Other conditions
PERIODONTAL DISEASE, INFLAMMATION
AND CANCER
Research Highlights
The Association of Dental Plaque with Cancer Mortality in
Sweden
Soder B, Yakob M, et al. Dept. of Dental Medicine, Karolinska Institutet, Huddinge, Sweden BMJ
Open 2012;2;e001083. doi:10.1136/bmjopen-2012-001083
• Objectives: To study whether the amount of dental plaque,
which indicates poor oral hygiene and is a potential source of
oral infections, correlates with premature death from cancer.
• Methods: Prospective cohort study. 1390 randomly selected
healthy young Swedes followed from 1985 to 2009.
The Association of Dental Plaque with Cancer
Mortality in Sweden
Soder B, Yakob M, et al. Dept. of Dental Medicine, Karolinska Institutet, Huddinge, Sweden BMJ
Open 2012;2;e001083. doi:10.1136/bmjopen-2012-001083
Results: 4.2% of participants died during the study. Amount of
dental plaque between those who died and those who survived
was statistically significant with 1.79 times the overall risk of
death via scattered malignancies in men and breast cancer in
majority of women.
Conclusion: Increased amount of dental plaque may be
associated with increased cancer mortality. Further studies are
warranted.
Chronic Periodontitis and the Incidence of Head
and Neck Squamous Cell Carcinoma
Tezal M, et al. Depts. Oral Diagnostic Sciences, Oral Biology, Social and Preventive Medicine,
Otolaryngology, S.U.N.Y. New York, USA Cancer Epidemiol Biomarkers Prev 2009 18;2406.
• Objective: To assess the effect of chronic periodontitis on head
and neck squamous cell carcinoma (HNSCC).
• Methods: 473 HNSCC patients studied btw 1999-2005.
Periodontitis measured by alveolar bone loss (ABL).
• Results: Each millimeter of ABL was associated with >4-fold
increase risk of HNSCC. Chronic periodontitis may be an
independent risk factor for HNSCC.
Periodontal Disease May Associate with Breast
Cancer
Soder B, et al. Dept. of Dental Med., Division of Periodontology, Karolinska Institutet, Huddinge,
Sweden. Breast Cancer Res Treat. June 2011; 127(2):497-502
• Objective: To evaluate the association between periodontal
disease, missing molars and breast cancer.
• Methods: Prospective study of 3,273 subjects ages 30-40 at
baseline.
• Results: Chronic periodontal disease accompanied by missing
molars associates statistically with increased incidence of
breast cancer.
A Review of the Relationship Between Tooth Loss,
Periodontal Disease, and Cancer
Meyer M, et al. Harvard School of Public Health Dept. of Epidemiology, Boston, MA. USA Cancer
Causes Control 2008 19:895-907
• Objectives: A review of 18 published studies demonstrating
relationships and possible mechanisms of action between
tooth loss, periodontal disease and various cancers. Controlled
for smoking, demographics and other possible confounding
factors.
Summary
Relationships between teeth and organs
Relationships between periodontal disease, inflammation and
cancer
Relationships between heavy metal toxicity, inflammation and
cancer
Natural agents with anti-inflammatory/anti-microbial/anticancer properties:
• Modified Citrus Pectin
• Tibetan Herbal Formula
• Honokiol
• Vitamin D3