Metabolic Energy - Metabolism Foundation

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Transcript Metabolic Energy - Metabolism Foundation

Metabolic Energy for
Dummies:
A quick look at
Cellular Metabolism
(Energetics)
By Richard Belicek
Introduction:
This presentation will cover the
general steps that nutrient
sources take to be utilized by
the body and how energy is
created through metabolism.
What is Metabolism?
metabolism defined: the total chemical
activity and flow of resources that occurs
within an organism’s boundary.
Where does it start?
Nutrient sources from food.
Foods such as steak, pizza, salad,
ice cream and chocolate are broken
down into these MACROMOLECULES:
Proteins
Fats
Carbohydrates
Macromolecules to
Simple Subunits
Proteins = Amino Acids
Fats = Fatty Acids and Glycerol
Carbohydrates = Simple Sugars
Subunits follow
metabolic pathways
Amino Acids
>Protein catabolism = Acetyl CoA
>Gluconeogenesis = Pyruvate
Fatty Acids and Glycerol
>Oxidation = Acetyl CoA
>Gluconeogenesis = Pyruvate
Simple Sugars (Glucose)
>Glycolysis =Pyruvate
Glycolysis
The sequence of rxns
that convert glucose
into pyruvate
Glycolysis
Occurs in the Cytoplasm
Aerobic or Anaerobic
Glucose enters the glycolytic
pathway
ATP: gross= 4, net= 2
NAD = 2 NADH, transported to the
Electron Transport Chain (ETC)
The Krebs Cycle
aka:
Tricarboxcyclic Acid
Cycle or
Citric Acid Cycle.
Krebs Cycle
Pyruvate enters cycle
2 cycles per Pyruvate molecule
1 ATP is produced per cycle
NAD and FAD = 6 NADH and 2 FADH2
NADH and FADH2 are transported to
the (ETC)
Electron Transport Chain
Electron Transport Chain
Occurs in the Cristea of the
mitochondria
NADH and FADH2 are oxidized
Hydrogen and electrons are carried
along chain transfer energy
Electrochemical gradient = ATP
O2 final acceptor = H2O
Electron Transport Chain
(1 NADH = 3 ATP, 1 FADH2 = 2 ATP)
Krebs Cycle = 8 NADH = 24 ATP
= 2 FADH2 = 4 ATP
For glycolysis (1 NADH= 2 ATP)
Glycolysis = 2NADH = 4 ATP
Overview:
Summary
Glycolysis
Krebs Cycle
Electron Transport Chain
Total ATP = 36 net
NO
Questions, Thank you.
HOORAY!
Thank you
Have a good break!!