Transcript Oral Care

Oral Care
Our product range
They are mineral salts:
Mineral/
cation¹
(Ca, Zn, …)¹
Anion²
FURDENTYL
(Glycerophosphate, nitrate, …)²
 FURDENTYL™
 FURDENTYL CZn
 FURDENTYL NK
 FURDENTYL ASr Against Dentinal hypersensitivity
 FURDENTYL CSr
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FURDENTYL™
FURDENTYL™ is a Calcium glycerophosphate (CaGP) (US GRAS approved)
It has a cariostatic action and a role as a nutritional supplement
It can be used alone for its intrinsic anticaries activity or combined with
NaMFP for its enhancing effect on the anticaries activity of fluorine
FURDENTYL™ can be used:
•
Locally: Toothpaste, mouthwash, chewing gum, before & after brushing
solutions
•
Orally: Tablets
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FURDENTYL™
Biological interests of the Glycerophosphate anion:
 An organic anion
 A mineral element vector
 Has a special biological role in the body’s essential metabolic reactions
Because of its combination with calcium, an appraisal of the anion’s
intrinsic biological properties can be made.
 Cariostatic activity
 Role in the membrane cell and vital organs (especially the brain) tissues
constitution
Hence FURDENTYL role as a nutrient besides its anticaries action.
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FURDENTYL™
Being a nutrient & a cariostatic agent renders FURDENTYL
particularly interesting in the case of individuals whose intellect and
physique are still developing, such as teenagers and children.
Dental caries is an infection, usually bacterial in origin, that causes
demineralization of the hard tissues (enamel, dentin and cementum) and
destruction of the organic matter of the tooth, usually by production of
acid by hydrolysis of the food debris accumulated on the tooth surface
FURDENTYL action mode:




Acts as a buffer power against the saliva’s pH
Helps mineralizing the tooth (Ca & P supplement)
Improves the fluorine fixation
Improves NaMFP’s role
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FURDENTYL™
Tests
Subjects: 923 children (11-12 years old)
Design: Double blind study
Toothpaste:
 Control group: Calcium carbonate
 Active control group: calcium carbonate + 0,76% NaMFP + 0,13 % CaGP
 The fluorine concentration in each toothpaste is 1 ppm
Duration: 4 years
Results:
 Clinical examination of the teeth (optic fibre)
 X-rays of molar & premolar teeth
 Examination once a year
 Results at the end of the 4 years
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FURDENTYL™
Clinical examination
Clinical examination
D.F.S.
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9 ,8 9
8 ,5 5
10
8
 Group treated with
CaGP/NaMFP combination has a
greater cariostatic activity
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4
2
0
Activ e contr ol
(NaMFP)
T r eated
(NaMFP + CaGP)
Gr oups
X-ray examination
X-ray examination
D.F.S.
2,5
2 ,1 4
1 ,6 3
2
1,5
 An improvement in the NaMFP
performance is observed when
used with CaGP
1
0,5
0
Activ e contr ol
(NaMFP)
T r eated
(NaMFP + CaGP)
Gr oups
DFS: Decayed & Filled Surfaces
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FURDENTYL™
Dissolution of enamel
% of reduction
25
20
20
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 A decrease in the enamel
dissolution is observed when
NaMFP is combined with CaGP
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10
5
0
Activ e contr ol
(NaMFP)
T r eated
(NaMFP + CaGP)
Gr oups (t oot hpast e)
300
231
 The fluorine hydroxyapatite
content is greater in the group
treated by the combination
FHA (ppm F-)
250
168
200
150
100

Optimal ratio : CaGP/NaMFP = 10:1
50
0
Activ e contr ol
(NaMFP)
T r eated
(NaMFP + CaGP)
Gr oups (t oot hpast e)
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FURDENTYL™
Physical appearance:
 A white amorphous or crystalline powder, odorless & tasteless
 A white powder, acidified by 15% citric acid content, with a slightly
acid taste & alcoholic smell
 A clear slightly syrupy liquid , with a light acid taste and an alcoholic
smell (a 50% calcium glycerophosphate liquid)
Quality-Pharmacopoeia:
 FURDENTYL powder: BPC 1963, FCC III, JP 8, NF X,PF X
 FURDENTYL acidified powder: with a 15% citric acid content:
pharmaceutical grade
 FURDENTYL 50% aqueous solution: Neutral calcium glycerophosphate
+ acidified calcium glycerophosphate + free glycerophosphoric acid:
pharmaceutical grade
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FURDENTYL ZnC
FURDENTYL ZnC (Zinc citrate) is considered a safe and appropriate
ingredient for tartar control and antigingivitis oral care products and has a
history of use as a dietary supplement
Tartar forms in the mouth when plaque mineralizes on your teeth. The
resulting hard deposits (calcified plaque or tartar) can only be removed by
a dentist or hygienist.
Zinc citrate helps prevent tartar buildup by preventing plaque from
hardening (calcifying).
Gingivitis is a disease of the gums that occurs when bacteria accumulate
on teeth, producing toxins and irritants that lead to red, puffy gums. If left
untreated, gingivitis can result in tooth loss and other health problems.
Zinc citrate helps prevent gingivitis by inhibiting bacterial accumulation
on teeth and gums.
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Dentinal hypersensitivity
Dentine

Dentine
This hydrodynamic
hypersensitivity
contains many
flow
thousands
is
can
sensation
be increased
of microscopic
felt when
by cold,
thetubular
air
nerves
pressure,
inside
the
structures
drying,
dentin of
that
sugar,
the
radiate
teeth
sour (dehydrating
outwards
are exposed
from
to
chemicals),
the pulp;
environment.
these
or forces
dentinal
acting
tubules
ontoare
thetypically
tooth. 0.5-2 micrometres in diameter.
The
Changes
sensation
in thecan
flow
range
of the
from
plasma-like
irritation biological
all the wayfluid
to intense,
present in

orpain.
cold
foodsensitivity
or
and
are
typical
shooting
theHot
dentinal
tubules
This
candrinks,
trigger
can
mechanoreceptors
bephysical
caused pressure
by several
present
factors,
on
triggers
in those
with
teeth sensitivity.
including
nerves
located
wear,
at
decaying
theindividuals
pulpal
teeth
aspect
or
exposed
thereby
tooth
eliciting
roots.
a pain
response.
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Dentinal hypersensitivity
The most cheap & efficient first line of treatment is a toothpaste
containing a desensitizing active ingredient such as:
 Potassium Nitrate
 Strontium Chloride
 Strontium Acetate
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Potassium Nitrate
“The most widely used active ingredient in desensitizing
toothpaste”
Potassium ions work by blocking the synapse between
nerve cells, reducing nerve excitation, and the
associated pain.
Potassium Nitrate is also reported to obliterate the
tubules, reducing the fluid flow in them, ultimately
reducing dentin hypersensitivity.
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FURDENTYL SrA & SrC
FURDENTYL SrC (Strontium Chloride) forms a barrier
over microscopic tubules in the dentin containing nerve
endings that have been exposed by gum recession.
FURDENTYL SrA (Strontium Acetate) works by
providing a physical plug within the microscopic
channels which helps to prevent the response to
triggers which can cause the short, sharp pain of
sensitive teeth.
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