Transcript Nanodiamond Drug Delivery

Nanodiamond Drug Delivery
Austin Ramos
Biomedical Engineering, URI
BME 281
Nanodiamonds
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Nanoparticles that are less than 100 nm in diameter (1)
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Nanodiamonds are useful
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Biocompatibility
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Functional versatility
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Unique surface electrostatics
Drug delivery
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Bypassing chemoresistance
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Controlled delivery
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Intracellular tracking (2)
http://www.itc-inc.org/nanodiamond.html
Chemotherapy
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Treating cancer with chemical substances
namely chemotherapeutic agents like Paclitaxel
(PTX)
Many side effects of Chemotherapy are caused
cytotoxic drugs that kill rapidly dividing cells in
the body whether or not they are cancerous (3)

Bone Marrow

Hair follicles

Digestive tract
Drug Delivery
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A nanodiamond drug delivery system was built using
nanodiamonds 2-8nm in diameter
Small molecule drugs and nucleic acids are bound to
the surface of the NDs and delivered with better
efficacy (2)
Nanodiamonds are being tested for their ability to
deliver chemotherapeutic agents
Drug Delivery
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PTX is attached to the
nanodiamonds through
fluorescently labeled
oligonucleotide strands in
addition to anti-EGFR
monoclonal antibodies

Anti-EGFR antibodies
improve delivery and
keep the drug inside
the cancer cell (2)
(2)
Experiment
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Two breast cancer cells
MCF7 and MDA-MB-231
were used and tested in vitro
Free PTX
PTX-DNA@ND (untargeted
PTX on ND)
PTX-DNA/mAb@ND
(targeted PTX on ND)
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When compared with free
PTX the targeted and
untargeted improved the
effectiveness of the drug
significantly
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The targeted PTX showed the
best results but was not
significantly better than the
untargeted PTX in MCF7 cells
In MDA-MB-231 cells the
targeted PTX was nearly twice
as effective as the untargeted
PTX
(2)
Conclusion
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Nanodiamonds could be a very effective drug
delivery system according to these results
NDs are able to significantly increase the
efficacy of
Nanodiamonds could also be used for imaging
and diagnostics if they are proven to be safe
and effective enough
Questions
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Works Cited
1.) Jong, De, and Paul JA Borm. "Drug Delivery and Nanoparticles: Applications
and Hazards." International Journal of Nanomedicine IJN(2008): 13349. Pubmed. Web.
2.) Zhang, Xue-Qing et.al. "Multimodal Nanodiamond Drug Delivery Carriers for
Selective Targeting, Imaging, and Enhanced Chemotherapeutic Efficacy." Adv.
Mater. Advanced Materials 23.41 (2011): 4770-775.Google Scholar. Web. 29
Sept. 2015.
3.)"Chemotherapy." Wikipedia. 19 Sept. 2015. Web. 04 Oct. 2015.
<https://en.wikipedia.org/wiki/Chemotherapy>.
http://www.itc-inc.org/nanodiamond.html