Transcript of Regenerative Medicine

The Biotechnology
Center of Excellence
Bringing Biotech from the
Bench to the K-12 Classroom
Event: Regenerative Medicine Webinar
Date: May 22, 2014, 4pm & 7pm CST
Location: Lindblom Math & Science
Academy
Hortense Brice, Presenter
[email protected]
Dr. Emily Ferrin, Facilitator
[email protected]
BCoE.net
osep.northwestern.edu
Webinar Objectives
 As a Result of Webinar Participation, You
Will:
1. Realize the Need for Regenerative Medicine
Practices and Procedures
2. Identify the Tools and Technologies of
Regenerative Medicine
3. Understand the Challenges, Promise and
Potential of Regenerative Medicine
4. Identify the Potential Benefits of Regenerative
Medicine to America’s Costly Health Care
System
“Body Builders”: The Emerging
Science of Regenerative
Medicine
The Beginning………
Charles Vacanti & Robert Langer (1997)
Characterizing Regenerative
Medicine
1. Regenerative medicine is a broad definition for innovative medical therapies that will
enable the body to repair, replace, restore and regenerate damaged or diseased
cells, tissues and organs. (Mayo Clinic)
2. Science Merges with Technology to Achieve Self-Healing
• Regenerative medicine uses procedures to repair or replace damaged or diseased
tissues and organs—Many traditional therapies only treat symptoms.
3. Tools and Procedures (Biofabrication or Additive Manufacturing) of Regenerative
Medicine
• Tissue Engineering: Tissue Repair/Replacement and Lab Grown Organs
• Technologies
 Stem cells
 Natural and Synthetic Scaffolds
 3-D Printing and Chip Technologies
4. Highly Interdisciplinary Field where Biology and Chemistry meet:
• Engineering
• Material Science
Areas of Regenerative Medicine
1. Artificial Organs: Medical Devices
(Lab Grown Bladder)
2.Tissue Engineering & Biomaterials
Scaffolds
Areas of Regenerative Medicine
3. Cellular Therapies
•
•
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Use of Stem Cells (From Patient)
Development of Regenerative
Medicine Treatments.
Enhance Regeneration of Tissues
and Organs.
4. Clinical Trials
•
•
Many Currently in Progress.
NIH and Private Organizations.
Regenerative Medicine
Procedures/Protocols
Engineer Scaffolds
•
Spaghetti
Highways
Hydrogel
Ear Scaffold
Regenerative Medicine
Procedures/Protocol
Seed Scaffold With Stem Cells
Regenerative Medicine
Procedures/Protocol
• Incubate Seeded Scaffold in Bioreactor
• Transplant into An Animal Model
Regenerative Medicine And
PRP Therapy
• PRP: Platelet Rich Plasma Therapy
• Concentrate Platelets from Patients Blood
Sample
• Platelets Contain Cytokines and Growth
Factors
• PRP Accelerates Healing and Reduces
Pain
• Bill Nye “The Science Guy” and PRP
Therapy
Regenerative Medicine Pioneer
Wake Forest Institute for Regenerative Medicine (WFIRM)
Dr. Anthony
Atala
•First to Engineer/Transplant Lab-Grown Organ
into a Human
•Transplant was Successful
•Currently Developing Organ on a Chip Program
Regenerative Medicine Pioneer
Dr. Paolo Macchiarini (Karolinska Institute)
•2008: Implanted World’s First Donor Trachea
•Recipient: Claudio Castillo
•Survived Procedure—Now Has Normal Respiratory
Function
Regenerative Medicine Pioneer
McGowan Institute of Regenerative Medicine
(University of Pittsburg)
•Removed Cells from Pig
Bladder Extra Cellular Matrix
(ECM)
•Dried: Forms “Pixie-Dust”
•Re-grows Severed Digits and
New Muscle Tissue
Dr. Stephen Badylak
Regenerative Medicine Pioneer
AFIRM: Armed Forces Institute Of
Regenerative Medicine.
•Treatment Procedures for Severely Wounded Soldiers
•Funded and Managed by US Army
•Partnership with Wake Forest Institute for Regenerative
Medicine
Regenerative Medicine
Innovator
Dr. Geraldine Hamilton (Wyss Institute)
Organ on a Chip Technology
(Drug Testing Tool)
Regenerative Medicine
Innovator
Jordan Miller (Rice University)
• Uses 3-D Print Technology
• Engineers Blood Vessels Using Sugar
Regenerative Medicine
Innovator
Ramille N. Shah, PhD (Northwestern University)
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•
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Leader in Field of 3D-Printable Materials
Engineers new 3D-Inks
Creates Porous Scaffolds
Technique: Additive Manufacturing
(Nanofiber Scaffold For
Cartilage Regeneration)
Regenerative Medicine Challenges
1. Design of Biomaterials that Function in
the Body
2. Getting Enough Cells and Cell Types for
Engineering Tissues and Organs
3. Vascularity: Engineering Blood Vessels
that Supply Nutrients, Oxygen and
Signals to Bioengineered Tissues and
Organs
4. Cost of Tissue and Organ Development
Procedures
Organ Decellularization Approach
Dr. Harald Ott
http://www.youtube.com/watch?v=5wfdhB_V
yJw
Challenge To Regenerative
Medicine
Bioengineering of Organs
Potential of Regenerative Medicine
Chip Technology
• Reduces Need for Animal Testing
• 3-D Printed Organs on Chips Used to Test
Vaccines
Promise of Regenerative Medicine
3-D Printer Creates Heart Membrane
3-D Elastic Membrane Fits Heart’s
Epicardium
The Business of Regenerative
Medicine
Organovo
3-D Bioprinting Company
 Started A Collaboration with NIH (January 2014)
 Goal: Bioprinting of 3D Living Tissues
• Eliminate Challenges to New Therapy
Development
• Animal Models: Poor Predictors of Drug Efficacy
and Toxicity
The Business of Regenerative
Medicine
Tengion
A Biotechnology Company
 Company Platform for Engineering
Tissues/Organs
 Organ Regeneration Process
o Doctors send Tissue Sample from Diseased or
Failing Organ to Tengion
o Tengion Selects and Multiplies Healthy Cells
o Place Cells on an Organ-Shaped Scaffold
o Result: A Neo-Organ for Transplant
Futuristic!
Stem Cells + Organ Scaffold + 3D Printer
= Libraries of Replacement Organs?
Regenerative Medicine
Summary
• Regenerative Medicine Approaches
o Use of Patients Stem Cells
o 3-D Bioprinting of Tissues and Organs
o Organ Decellularization
o PRP: Plasma Rich Platelet Therapy
Human Treatment
Veterinary Medicine Therapy
Regenerative Medicine And
Healthcare
• New Era in Medicine: Move from
Treatment to Cures (Self-Healing)
• Eliminate Organ Transplant Shortage
• Reduce Health Care Costs
• Now A Medical and Commercial Reality
 Over 60, 000 Stem Cell Transplants Worldwide
 2012: Cell Therapies Generated More Than
$900 Million
Thank you!
osep.northwestern.edu
[email protected]
[email protected]