9.4 Notes mb changes
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Transcript 9.4 Notes mb changes
9.4 Notes
ID, Collection of Evidence
Objectives
Describe the laboratory tests normally
used to perform a routine drug
identification analysis
Understand proper collection and
preservation of drug evidence
Drug Identification
Either a specimen is a specific drug or it is
not
Chemists must be prepared to support and
defend the validity of the results in a court of
law
Screening test – reduces possibilities
first test is color test
Confirmation test - pinpointing
Drug Identification cont.
The procedures must be able to confirm that
the likelihood of any other substance
responding in an identical manner to a
certain drug is so minimal that there exists
no other conclusion but reasonable scientific
certainty
Analytical schemes
1. Color tests
2. Microcrystalline tests
3. Chromatography
4. Spectrophotometry
5. Mass Spectrometry
Color Tests
1. Marquis reagent – purple with
heroine and morphine; orange with
amphetamines
2. Dillie-Koppanyi – violet blue with
barbiturates
3. Duquenois-Levine – ABC layers
with layer C purple with marijuana
4. Van Urk – purple/blue with LSD
5. Scott Test – ABC (A with cocaine,
blue to pink in B, and blue again in C
layer)
Microcrystalline Tests
Chemical reagent
added to drug on slide
Crystalline precipitate
with unique structures
results
Chromatography
Uses TLC (Thin Layer
Chromatography) and gas
Requires the Rf
comparison of known and
questioned drugs
Accompanies color and
crystal test
Spectrophotometry
Absorption of light in
the UV and IR regions of
the spectrum
Establishes probable
drug
IR can specifically ID a
substance
Mass Spectrometry
GC/MS
Utilizes the
fragmentation pattern of
sample molecules which
serves as a fingerprint
Can be used to
separate components of a
complex drug mix
ID of Marijuana
Based on botanical
features
Cystolithic hairs – short
hairs, shaped like bear
claws
DuQuenois-Levine color
test
Without leaf, TLC is used
Collection & Preservation of
Drug Evidence
Original container
Airtight container if glue sniffing
Packages marked
Background information