Transcript Treponema pallidum

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Vasculitides
Awesome
Associations
RA Rx
Rheum with
a View II
Vasculitides
Awesome
Associations
RA Rx
Rheum with
a View II
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Involvement of the ophthalmic
artery causing sudden
irreversible blindness is 1 sign of
this large-sized vasculitis
What is giant cell or
temporal arteritis?
Coin lesions
+ pulmonary hemorrhage
+ RPGN
+saddle-nose deformity
What is Wegener’s
granulomatosis?
A.k.a. Kussmaul-Meier disease,
this medium-sized vessel
vasculitis is common in Hep B
and can show a classic “string of
beads” angiographic picture
What is polyarteritis
nodosa?
Papable purpura, arthritis and
abdominal pain make up the
classic triad of this vasculitis
marked by IgA-immune
complex deposition
What is Henoch-Schonlein
purpura?
This vasculitis may be
associated with uveitis and
erythema nodosum, but most
typically known for recurrent
oral and genital ulcers, and a
(+) pathergy reaction
What is Behcet’s
syndrome?
Most common gynecologic
maligancy in dermatomyositis
What is ovarian cancer?
Painless yellow-brown
lesions in palms/soles in
reactive arthritis
What is keratoderma
blennorrhagica?
Valvular abnormality in
ankylosing spondylitis
What is aortic
regurgitation?
Lung condition in
scleroderma with diffuse
cutaneous involvement
What is pulmonary
fibrosis?
Hematologic lab value
typically >5x normal in
Adult-onset Still’s disease
What is ferritin?
A folic acid analogue used to
treat moderately active RA, it
confers clinical improvement and
possible survival benefit
What is methotrexate?
This anti-malarial drug has been
shown to reduce inflammation
and joint erosions but may also
cause rare ophthalmologic
toxicity
What is
hydroxychloroquine?
(Plaquenil)
An FDA-approved therapy for
RA, this sulfonamide is now a
mainstay of outpatient treatment
for inflammatory bowel disease
What is sulfasalazine?
A chimeric monoclonal
antibody against TNF-ά, it
requires a pre-treatment PPD
to rule out latent TB
What is infliximab?
(Remicade)
A recombinant DNA drug, it is
produced by combining IgG1
and human TNF receptor—the
so-called “master regulator” of
inflammation in autoimmune
diseases
What is etanercept?
(Enbrel)
View Q1
What is rheumatoid
arthritis?
(Boutonniere deformity)
What is gout?
(Ear tophus)
What is dermatomyositis?
(shawl sign)
View Q4
What is psoriatic
arthritis?
(Dactylitis, DIP
involvement, nail pitting)
View Q5
What is scleroderma?
(sclerodactily)
HIV
Buzz words
in ID
STDs
Drugs for
Bugs
HIV
Buzz
words in ID
STDs
Drugs for
Bugs
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The risk for this fungal infection
increases when the CD4 count
3
drops below 200 cells/mm
What is Pneumocystis
jiroveci pneumonia?
Multiple brain lesions or
encephalitis in
patients with severe HIV
What is
Toxoplasmosis?
This HIV drug will make you live
your dreams--and nightmares!
What is efavirenz?
(Sustiva)
HIV drug class most
commonly associated with
fat redistribution syndrome
or lipodystrophy
What are protease
inhibitors?
The First and Only Once-Daily
Single Tablet HIV Treatment
What is Atripla?
(efavirenz/emtricitabine/tenofovir)
Hot tub folliculitis
What is
Pseudomonas aeruginosa
infection?
Gardener
+ painless nodule on the wrist
+ palpable axillary lymph node
What is Sporotrichosis?
(Sporothrix schenckii)
Hog farmer from Arkansas
+ periorbital edema
+ joint and muscle pains
+ eosinophilia
What is Trichinosis?
(Trichinella spiralis)
Post-renal transplant patient
+ gram positive rod meningitis
What is Listeriosis?
(Listeria moncytogenes)
Seawater exposure
+ hemorrhagic bullae/
necrotizing fasciitis
+ septic shock
What is Vibrio vulnificus
infection?
Painless penile ulcer with clear
base but indurated edges
What is syphilis?
(Treponema pallidum)
Painful vesicles in the groin
and genital area
What is Herpes simplex
type 2 infection?
This tender genital ulcer will
make you “cry”!
What is chancroid?
(Haemophilus ducreyi)
Small painless vesicle that can
cause painful and suppurative
lymphadenopathy
What is Lymphogranuloma
venerum?
Beefy red painless ulcer
associated with pseudo-buboes,
subcutaneous swelling
but not lymph nodes
What is granuloma inguinale?
(Calymmatobacterium
granulomatis)
Treponema pallidum
What is Penicillin?
Sporothrix schenkii
What is Itraconazole?
Borrelia burgdorferi
What is Doxycycline?
(Tetracyclines)
Bordetella pertussis
What is Erythromycin?
(Macrolides)
Chloroquine-resistant
Plasmodium falciparum
What is Mefloquin?
Medical
Milestones
1 German and 2 French scientists
shared the recently awarded Nobel
prize for Medicine for discovering
these two viruses causing global
disease and death
What are HPV and HIV?
Thank you for
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