Transcript Drug Delivery Chip

Jonathan Ims
BME 281 Sec. 1
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1964, Folkman demonstrated a silicon rubber pill for
low molecular weight drugs.
1970s, Langer expanded on Folkman
◦ Polymers that could carry macromolecules
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Mid 1990’s the idea of a drug releasing microchip by J.
Santini Jr.
◦ J. Santini Jr. went to MIT
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Mechanical Micro Pumps
◦ Need a physical actuator
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Non-mechanical Micro Pumps
◦ Converts some form of energy into kinetic momentum
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Key components
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High Flow Rate
Low Voltage (between 5 -12V)
Reliability of the System
Bio-compatibility
Frequency
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The width and length of each chip varies but
the depth of the chip remains between
(0.5mm to 1mm)
8 reservoirs can be found in an area of
1.77mm by 1.44mm
The reservoirs can hold a total of 200nL
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Patients with Chronic Disease
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Diabetes
Epilepsy
Osteoporosis
etc.
It is not meant to replace prescription pills for common
illnesses such as the flu.
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Surgery
Unwanted Side Effects
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Heat
Pressure
pH
Bio-compatibilty
Reservoir size
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Increase the efficiency of drug delivery
Self-drug releasing chips
Different types of drug release
Better bio-materials