Transcript Slide 1

ABSTRACT
THE INFLUENCE OF PROPILENGLYCOL ADDITION TO
PERCUTANEOUS PENETRATION OF KETOPROFEN IN VITRO
RELEASE FROM COLD CREAM BASES
RICMA MEGA SARI
Ketoprofen (KP) is a potent non-steroidal anti-inflamatory drug which is used
for the treatment of rheumatoid arthritis. The oral administration of KP can cause
gastric irritation and renal adverse effects. Topical application of the drug can bypass
gastrointestinal disturbance and provide relatively consistent drug levels at the site of
action. The research concerning influence of propilenglycol addition to
percutaneous penetration of ketoprofen in vitro release with various concentration of
propilenglycol (5%, 10% and 15%) passed lipid membrane from cold cream bases.
The physical use propilenglycol 0% ( formula A) with other concentration of
propilenglycol (formula B=5%, C=10% and D=15%) to compare the influence of
propilenglycol addition to percutaneous penetration of ketoprofen in vitro release
from cold cream bases. From penetration test result of ketoprofen passed lipid
membrane got flux. The result was analyzed by statistic programmed of SPSS 11.0
using one way anova analysis of variance with degree of believe 95% (α = 0,05) have
significant difference to flux of formula A, B, C and D of the ketoprofen cream and
the difference was analyzed by Honestly Significant Difference (HSD). The result of
flux formula A is 0.4839 µg/cm2/menit with coefficient variation 2.11%, formula B
0.5153 µg/cm2/menit with coefficient variation 1.57%, formula C 0.7773
µg/cm2/menit with coefficient variation 1.29% and formula D 0.5683 µg/cm2/menit
with coefficient variation 1.73%. The conclusion, percutaneous of penetration
ketoprofen will be increase along with the increase of the propilenglycol
concentration but maximum enhancing activity was obtained from cold cream
containing 10% propyleneglycol because more those concentration fluks and
permeability will be decreased.
Keyword : Ketoprofen; drug release; percutaneous absorbtion; propilenglykol.