Transcript Antiretroviral Provision in Tanzania

Antiretroviral Provision in
Tanzania
Ms Mary Masanja
Ms Emma Lekashingo
Background
• Population of the country is estimated to
be 35 million.
• The HIV/AIDS prevalence is 9.6%
• Estimated number of people living with
HIV/AIDS virus is about 2 million.
• The country is embarking to WHO’s 3by5
mission to provide ARV to about 220,000
patients by the year 2005.
Drugs to be used:
First line drugs for adults are:
• Stavudine/Lamivudine /Nevirapine
(d4T/3TC/ NVP)
• Stavudine/Lamivudine/Efavirenz
(d4T/3TC/ EFV)
• Zidovudine/Lamivudine/Efavirenz
(AZT/3TC/EFV)
• Zidovudine /Lamivudine /Nevirapine
(AZT/3TC/NVP)
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• These drugs will be used depending on the
different conditions the patients will present with.
For patients with Hb less than 7gm/dl:
Stavudine 40 mg/Lamivudine 150 mg/Nevirapine
200 mg twice daily (> 60 kg body weight).
Stavudine 30 mg /Lamivudine 150 mg/Nevirapine
200 mg twice daily (< 60 kg body weight).
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For TB patients the regimen will be:
Stavudine 40 mg/Lamivudine 150 mg twice
daily and Efavirenz 600 mg once daily at
night (> 60 kg weight).
Stavudine 30 mg /Lamivudine 150 mg twice
daily and Efavirenz 600 mg once daily at
night (< 60 kg weight).
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For patients who have Nevirapine
intolerance, the regimen will be:
Zidovudine 300 mg/Lamivudine 150 mg
twice daily and Efavirenz 600 mg once
daily at night.
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Patients with peripheral neuropathy who
cannot use Stavudine, the regimen will be:
Zidovudine 300 mg/Lamivudine 150
mg/Nevirapine 200 mg twice daily.
There are also second line drugs which
includes combination of two nucleoside
reverse transriptase inhibitors with one
protease inhibitors.
Control of these drugs
TFDA: Tanzania Food and Drug Authority
• Control the importation of all drugs in the
country including ARV’s.
• Developed the guideline for the distribution
and storage of ARV’s in the country.
• Laboratory for the quality control of
pharmaceuticals entering the country.
Control cont…
• Port of entry inspection.
• Mini lab kits (WHO,MSH).
• ADR monitoring.
Thank You!