315 LECTURE #1
Download
Report
Transcript 315 LECTURE #1
Drug
Classification
Lesson 1
Psychopharmacology
Study of drugs that affect nervous
system
Study effects of the drug
e.g. prenatal methamphetamine
Drugs as tools to study functions of
nervous system
e.g., cocaine & reward systems ~
My Interests
Prenatal & postnatal consequenses
Drugs of abuse
Environmental teratogens
Prenatal
effects on neural development
Postnatal behavior
Postnatal
Addiction ~
Drug effects are variable!
Course Goal: Understanding
factors that produce variability
1. Pharmacological
2. Neurophysiological
3. Psychological
4. Survey of specific drugs ~
Psychoactive Drugs
Drug
Biologically Active
chemically alters cell structure/function
Exclude: Natural Foods/Water
Alters function of nervous system
Consciousness
Emotions
Perceptions
Behavior ~
Drug Names
1.
2.
3.
At least 3 names
Chemical name
describes molecular structure
Generic name
official legal name
Trade name
brand name
Street name
~
Example: Amphetamine
chemical
dl-2 amino-1
phenylpropane
generic
dl-amphetamine
trade
Benzedrine
street
speed, bennies,
whites, etc.~
Example: Valium
chemical
7-chloro--1-methyl-5-phenyl-3H1,4-benzodiazepin-2[1H]-one
generic
diazepam
trade
valium
street
tranks, downers, blues, yellows
Example: Lunesta
chemical
(+)-(5S)-6-(chloropyridin-2-yl)-7-oxo6,7-dihydro-5H-pyrrolo[3,4-b]
pyrazin-5-yl 4-methylpiperazine-1carboxylate
generic
eszopiclone
trade
Lunesta
street
?
Drug Equivalence
Important to know when prescribing
Chemical equivalence
identical chemical compounds
e.g., Miltown & Equanil (meprobamate)
Biological equivalence
different chemical compounds
affect the same systems in same way
e.g., Prozac vs. Zoloft ~
Drug Equivalence
Clinical equivalence
same behavioral effect
different chemical compounds
affecting different systems
e.g., thorazine vs. lithium ~
Drug Classification
Several schemes
use depends on goals
Not easy to classify
each drug wide range of properties
Psychopharmacology:
CNS & Behavioral ~
Text: CNS & Behavioral Effects
CNS Stimulants
Cocaine, amphetamine
CNS Depressants
Barbiturates, alcohol
Analgesics
Morphine, codeine
Hallucinogens
Mescaline, LSD, psilocybin
Psychotherapeutics
Prozac, thorazine ~
Drug laws & legal classification
Controlled Substances Act of 1970
5 schedules
abuse potential
medicinal value
Schedule I
high abuse potential
no accepted medicinal value ~
Drug laws & legal classification
Schedule II
high abuse potential
accepted medicinal value
Schedule III
moderate abuse potential
Schedule IV - low abuse potential
Schedule V - abuse potential < IV ~
Drug Schedules & Regulation
Schedule I
Cannot be prescribed
Research: tightly regulated
Schedule II
Can prescribe, but no refills
Research: yearly registration
Schedule III, IV, V
Prescribe up to 5 refills over 6
months ~
Classification Problems
Alcohol effects
General nervous system depressant
Effects depend on dose
Low dose behavioral excitation
High dose behavioral inhibition
What are the effects of alcohol?
It depends! ~
Another Example
Attention Deficit Hyperactive Disorder
hyperkinesis
Treatment: Ritalin
Methylphenidate
classified as a sedative?
No, a stimulant ~
No Magic Bullets!
Drug delivered into system
Affects all cells that have receptors
Desired effect
= therapeutic effect
All other effects
= side effects
All drugs have multiple effects ~
What are a drug’s effects?
IT DEPENDS
Many sources of variability
A focus of this course
Deciding to use a drug
weigh benefits vs. risks
there are always risks ~