Transcript DBS on Parkinson`s Disease By: Christopher Ross DeSanto BME

DBS on
Parkinson’s
Disease
By: Christopher Ross DeSanto
BME 181 / February 11, 2010
What is Parkinson’s Disease
?
Parkinson’s Disease
•
•
•
•
Neuro-degenerative
Disorder
Dopamine Deficiency
Causes emotional and
physical complications
Affects Substantia Nigra
P
h
y
s
i
o
l
o
g
y
of
P
a
r
k
i
n
s
o
n
’
s
Current Treatments of
Parkinson’s
•
•
•
•
•
No cure for Parkinson’s
Most Parkinson’s patients are on a drug
regimen
Parkinson’s Disease medication target
symptoms only
No medication ensures life-long stability
Most common drug today is Levodopa
•
•
•
•
Levodopa is converted into
dopamine
Does not produce dopamine
receptive cells
Does not stimulate cells to take
in dopamine
DBS is an alternative to
Levodopa
Deep Brain
Stimulation
What is DBS?
•
•
•
•
A Deep Brain Stimulator is a device
called a brain pace maker that is
implanted into the brain.
Connected to an IPG (implanted
pulse generator)
Sends electric pulses to the brain
that stimulate dopamine production
Placed on the VIM of the brain
DBS
•
•
•
•
A reversible procedure
Requires skull penetration
Nodes placed directly on
brain (lead)
Lead carries the charge
Statistics
•
•
•
•
•
80% of patients experience little to no
tremors after DBS use
For some patients medication is still
needed but for all it reduces dosage
needed
DBS has been reported to work for 4 to 6
years.
Everyone responds differently
Known to cause loss of feeling in face or
limbs
How DBS Came To
Be
•
•
•
•
•
Cures for Parkinson’s
began in 1909
Involved dangerous lesions
to the brain (lobotomies)
1947 created Stereoencephalotome
Placed electric nodes over
VIM section of brain
VIM still utilized today
against Parkinson’s with
DBS
Modern DBS Technology
Modern Applications
of DBS
•
•
•
•
New technology being
made yearly
Recently: RLS treatments
Sleep Disorder cure
Significant data has been
found that it works better
with those acute/ severe
symptoms
Where I see DBS going ...
Questions?