Transcript ppt

Accelerating Pharma IP Discovery
using Advanced Search Technology
Craig Stephens
CAS Vice President, Sales
Monday, April 4, 2016
Agenda
● Introduction to Chemical Abstracts Service (CAS)
● Trends in chemical research publications
● Prodrugs - a Case Study
CAS is a division of the American Chemical Society.
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Copyright 2011 American Chemical Society. All rights reserved.
CAS is the leading global source of chemical information
for scientific and patent research
•
•
Founded in 1907 to monitor,
abstract, and index the world's
chemistry-related literature and
make it available to the
scientific community
Headquartered in
Columbus, Ohio
CAS is a division of the American Chemical Society.
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Copyright 2011 American Chemical Society. All rights reserved.
CAS databases provide complete access to the world of
chemistry and related science
CAS is a division of the American Chemical Society.
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Copyright 2011 American Chemical Society. All rights reserved.
CAS analyzes global chemical information, including
extensive coverage of patents from Asia
Japanese Patent Office (JPO)
Republic of Korea (KR)
China (CN)
Taiwan (TW)
India (IN)
Hong Kong (HK)
Philippines (PH)
Singapore (SG)
Coming Soon
Malaysia!
CAS is a division of the American Chemical Society.
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Copyright 2011 American Chemical Society. All rights reserved.
CAS products streamline access to CAS databases to
speed the pace of scientific discovery
CAS is a division of the American Chemical Society.
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Copyright 2011 American Chemical Society. All rights reserved.
April 4, 2016
Patenting of new chemical research has accelerated,
especially patenting of Chinese chemical research
Chemistry Patent Publications, 1999-present
Documents in CAS Databases
China
Japan
USA
WIPO
120,000
100,000
80,000
60,000
40,000
20,000
0
1999
2000
CAS is a division of the American Chemical Society.
2001
2002
2003
2004
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2005
2006
2007
2008
2009
2010
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Increasingly, new chemical discoveries are being
disclosed through patent activities
Percentage of New Compounds Added to CAS REGISTRY from Patents
50%
45%
46%
40%
35%
30%
25%
20%
15%
10%
14%
5%
0%
1976
2010
Year
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Monday, April 4, 2016
“Patinformatics” is an emerging science that derives the
“big picture” from a multitude of patent documents
How has nanotechnology been used in the area of drug delivery?
Which pharmaceutical companies are developing prodrugs and what
technologies are they using?
Searcher
Analyst
Ideas
Broad Search
Strategy
Query
Large
Answer Set
Visualize
Discovery
Opportunities
Strategy
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Monday, April 4, 2016
Patinformatics: A quick study on Prodrugs
● Use search tools to create a document set: STN
● Export the document set to an analysis tool
● Perform analysis and visualization within STN AnaVist
– Automatically creates visualizations that are dynamically linked
– Enables evaluation based on comparisons of structured and unstructured
data
● Apply the results to a business situation
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April 4, 2016
Search technology can reveal new trends in drug
discovery
Search tools ensure comprehensive
retrieval of appropriate records
– Controlled Term thesauri focus on
targeted terminology used in a
database
– Substance search tools include
structure and sequence search
capabilities
Results from a technical database search
can demonstrate trends
– Display fields sort information for
further investigation
– Database tools facilitate in-depth
analysis and visualization
CAS is a division of the American Chemical Society.
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Copyright 2011 American Chemical Society. All rights reserved.
A thesaurus provides insight into pharmaceutical
terminology and a hierarchy to broaden/narrow studies
=> FILE CAPLUS
=> E PRODRUGS+ALL/CT
E1
0
BT2 Bioactive compounds (non-CA heading)/CT
E2
4081
BT2 Health products/CT
E3
43159
BT1 Drugs/CT
E4
4081
BT3 Health products/CT
E5
200542
BT2 Drug delivery systems/CT
E6
0
BT1 Pharmaceutical dosage forms (non-CA heading)/CT
E7
5509
--> Prodrugs/CT
HNTE Valid heading during volume 146 (2007) to
present.
NOTE A compound that must undergo chemical conversion
to a pharmacologically active form after
administration.
E8
OLD Drug delivery systems (L) prodrugs/CT
E9
OLD Pharmaceutical dosage forms (L) prodrugs/CT
E10
OLD Pharmaceuticals (L) prodrugs/CT
E11
UF
DDS prodrugs/CT
E12
UF
Drug precursors/CT
E13
UF
Pharmaceutical prodrug/CT
E14
UF
Pharmaceutical prodrugs/CT
E15
UF
Prodrugs pharmaceuticals/CT
********** END **********
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Modern technology helps develop interactive
visualization tools to speed drug discovery
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The Research Landscape reveals the “big picture” in
technology development
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Competitive trends in pharmaceutical research can be
discovered and explored in more depth
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Summary
● Scientific databases (CAplus) provide easy access to the rapidly
increasing amount of prior art in the pharmaceutical area
● Search products (STN) provide a powerful tool to precisely obtain
relevant patent information
● Analysis and visualization software (STN AnaVist) facilitate business
decisions by:
● Accurately interpreting technological trends
● Identifying leading companies in drug development
● Locating relevant prior art
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Right information for right business & project decisions
“STN offers all important scientific databases we need. This allows
comprehensive state-of-the-art searches on all our research topics.”
Dr. Bernhard Hostettler, Head of Intellectual Property Management,
Prionics, Swiss Animal Health Diagnostic Company
Improve
decision-making
Reduce risk
STN can help
leverage your IP
portfolio!
Increase workflow
efficiency
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Discover new
opportunities
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The world’s major pharmaceutical companies trust
information from STN
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April 4, 2016
New five-year “single source” contract with USPTO
STN databases offer the largest collection and depth of chemical
“and
related information compared to other commercial web based
databases.
… CAS is the only company that has a unique, proprietary, chemical
structure searching capability using its STN Express software. No
other source can successfully meet the USPTO's requirements.
“
USPTO, 20 August 2010
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April 4, 2016
Thank You.
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