Transcript Genostar - ChemAxon

Genostar Bioinformatics Solutions
Connecting, completing and exploring biochemical
and genomic data with Metabolic Pathway Builder
ChemAxon's User Group Meeting, June 3-4th
 Genostar 2009
Genostar: about us
 Located in the heart of the French Alps, near Grenoble
 Grenoble area
• Top center for research in France, outside Paris
21,000 researchers
200+ laboratories
 Strong life sciences research
• French National Institute for Research in Computer Science and
Control (INRIA)
• Atomic Energy Research Center (CEA)
• Institute for Structural Biology
• European Molecular Biology Laboratory (EMBL)
 Genostar 2009
Genostar: about us
 Genostar provides bioinformatics software, databases and
analysis services for microbial research
 Applications
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Vaccine discovery and development
Drug discovery
Diagnostics
Agro-foods
Environment
 Genostar 2009
Our offer: software, data and services
Products
 Metabolic Pathway Builder suite
Perform genomic, proteic, and metabolic research with a comprehensive software suite
 GenoAnnot / ProteoAnnot
Perform comparative genomic and proteic sequence annotation and reannotation
 PathwayExplorer
Perform comparative genomic and differential metabolic analyses
 MicroB Database
Integrate, rigorously cross-checked genomic, proteic, biochemical and metabolic data
on about 800 organisms
 KDB Explorer
Explore, visualize and highlight the metabolic and non-metabolic pathways specific to your organism
 PathwayExplorer
 GenoMirror
Local mirror to interactively explore KEGG data while maintaining research confidentiality
Services
We provide a full range of bioinformatics analysis services
 Genostar 2009
PathwayExplorer module
 Draws on heterogeneous data into a powerful entityrelationship model
genomic (GenomeReviews, EMBL, Genbank),
proteic (Swiss-Prot),
classification (Enzyme, GO, NCBI taxonomy…)
biochemical (KEGG ligand),
metabolic (KEGG pathways),
expression data
 Comparative genomics and metabolomics
• Integrates proprietary and public methods: EC prediction,
pattern inference, homologies and syntons computations…
• Interactive and specialized viewers
Marvin, Jchem Base
Interactively explore and visualize metabolic pathways
 Compare your own data with our reference database
 Genostar 2009
PathwayExplorer and ChemAxon (1/4)
Manage and display
chemical compounds
with Marvin
Run Chemaxon structural search
e.g: search compounds that contain
benzoate substructure
Explore compounds
extracted from KEGG
ligand database
 Genostar 2009
PathwayExplorer and ChemAxon (2/4)
Find and display biochemical
reactions that involve a
benzoate derived compound
 Genostar 2009
PathwayExplorer and ChemAxon (3/4)
Colorize reactions that involve
benzoate derived compounds
Colorize catalyzed reactions
Listeria Innocua
Bacillus Subtilis
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PathwayExplorer and ChemAxon (4/4)
Select a pathway in the KEGG map…
… and explore its genomic organization
Listeria innocua
Bacillus subtilis
Compare syntenic regions
• 1 operon in Bacillus
• 2 operons in Listeria
 Genostar 2009
Perspectives
 Extend Metabolic Pathway Builder capacities further in the
direction of cheminformatics
Increase connections to external biochemical and chemical databases
(ChEBI and UniPathway, PubChem)
Integrate 3D facilities
(PDB, PubChem, MarvinSpace)
Implement structural analysis, predict molecular properties
(Calculator Plugins - Chemical Terms)
 Extend partnerships to increase our capacity in drug
discovery and molecular design
 Genostar 2009
Thank you
Contact
Pierre-Emmanuel Ciron
[email protected]
+33 476 97 10 74
Sophie Huet
[email protected]
+33 476 97 10 78
Adrienne Kennard
[email protected]
[email protected]
www.genostar.com
 Genostar 2009
Partners