Transcript Document

Pharmacology
• Science that studies interactions of drugs with
organism on different levels (subcellular, cellular,
organ, systemic)
Studies:
- relationship between chemical structure and
biologic activity
- site of effect localisation
- mechanism of action
- fate of drug in organism
- evaluation of relationship between dose and
biologic effect
Clinical pharmacology
•
•
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is the science of drugs and clinical use of drugs
branches:
pharmacodynamics
pharmacokinetics
rational prescribing
adverse drug effects
drug interactions
toxicology
drug development
Pharmacogenetics
• study of genetic variation which cause
different response to drugs
• is taking into consideration one or only a
few genes
• e.g. of genetic variation: “slow and fast
acetylators“ (variation in the Nacetyltransferase gene)
Pharmacovigilance
• science of collecting, monitoring and
evaluating information of the adverse
effects of medications, biological products,
herbalism and other medicines
• from Greek pharmacon = drug
Latin vigilare
= to keep alert
Pharmacoeconomics
• study that evaluates the cost and effects of a
drug or drug therapy
• examples of pharmacoeconomic evaluation
types:
- cost – benefit analysis
- cost – minimization analysis