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ISTN Nanotechnology Development Industrial Science & Technology Network September 22, 2005 ISTN small technology for big marketsTM ISTN Inc. - An Introduction A small Contract Research company of 15 employees, including 9 Ph. D. research scientists Has superior knowledge and experience in water treatment, foaming insulation, adhesives, optical electronics, and biotechnology fields Located in York, PA with office, laboratories, and many analytical instruments Ongoing Joint-Venture and Projects in China, Taiwan, Korea, and other countries Collaboration with many Universities and Institutes in the United States and overseas September 2005 ISTN Inc. ISTN – Early Mover in Nanotechnology Founded in 1997 by Dr. Arthur J. Yang Former Insulation Research Director at Armstrong ATP grant for Nanopore Thermal Insulation – 1992 Develop organic-inorganic nanocomposites Functionalized silica materials (sol-gel chemistry) Polymer-metal composites Industrial Products September 2005 Opto-Electronics Biotechnology ISTN Inc. CSMG – Nanopore Reactive Adsorbent Selective Adsorption – significantly enhances reaction kinetics. High Capacity – nanopores, surface regeneration, selectivity S S H H Flexible Platform – Hg surface ligand groups can be designed to accomplish variety of functions, (adsorption, separation, catalysis, etc.) S H S H Integration – adsorption, catalysis, and reaction combined in one product Na+ S H +2 S H +2 S H S S H H S S S S H S S H H H HHgH S H Silica S S H H Iron Platform Technology with Tremendous Commercial Potential September 2005 ISTN Inc. Nanopore Enhanced Enzyme Device Key Properties Immobilized enzyme can be reused many times Reaction can occur in continuous flow mode instead of batch mode Product can be separated from reactants during reaction, which promotes reaction rate Reaction and separation done in one continuous flow operation Column can be regenerated by effluent wash after saturation Encapsulation of Biological Entity With Silica Process is suitable for large-scale operation and can be fully automated September 2005 ISTN Inc. Optical Coatings Wet chemistry process, no vacuum needed Sol-gel process to prepare optical transparent coatings Anti-glare/anti-reflective or high reflective coatings Low cost process Ready to apply to large surfaces Application including: lenses, solar panel, display screens, architecture glasses, protection films, etc. September 2005 R1 R2 R3 Rs T 20 18 16 Reflectance % 14 12 10 8 6 4 2 0 350 450 550 650 750 850 Wavelength (nm) ISTN Inc. Nanotechnology for Drug Delivery Collaboration with University of Michigan’s College of Pharmacy Silica-Chitosan Composite Funding: Phase I SBIR (2004) Applying for Phase II Low MW Protamine (LMWP) Funding: Phase I STTR, Phase II SBIR (2002) Pursuing IND from FDA Key Properties Key Properties Controlled release for ulcer treatment. Maximizes efficacy while minimizing side effects Drug use for non-toxic heparin neutralization which can also be used for drug and gene delivery Silica-Chitosan composite has increased residence time in stomach (highly acidic). Able to translocate through cell membranes (structural similarities to HIV-TAT protein) Entangled network of chitosan and silica molecules maintain structural integrity CSMG technology utalized to optimize thermolysin immobilization for continuous production of LMWP September 2005 ISTN Inc. Flexible Commercialization Strategy Objective Advantage Customer and end-user relationship to test CSMG for novel applications Sales/marketing partnerships to complement own direct sales force Licensing Joint development agreements with large corporations Transactions to utilize CSMG for specific applications New Company Joint venture / spin-off with corporate or institutional investor Significant investor involvement in strategic and management decisions Strategic Alliances September 2005 ISTN Inc.