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Voluntary Wheel Running Enhances the Locomotor-Activating
Effects of Methamphetamine in Mice
SFN Poster # 62.17
No Running Wheel
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A c u te M e th W ith d r a w a l
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Unlike previous research showing that voluntary exercise attenuates the
acute locomotor-activating effects of cocaine in rats (Smith and Witte
2012), the present experiment found that exercise mice did not differ from
sedentary mice following any methamphetamine dose during the rising
phase (Hour 4).
The present experiment found that exercise mice were more active, reared
more and spent more time in the center compared to sedentary mice during
the declining phase (Hours 5 – 8) following the moderate (0.5 mg/kg) and
high (1.0 mg/kg) methamphetamine injections, suggesting that
methamphetamine withdrawal induces anxiety in sedentary mice and that
exercise ameliorates the anxiety.
It has been shown that physical exercise reduces anxiety in mice, as
measured by the open-field test (Salam, Fox, Detroy, Wohl and Falls 2009).
Moreover, physical exercise reduces the anxiety associated with drug
withdrawal in rodents (see Lynch, Peterson, Sanchez, Abel and Smith,
2013, for a recent review) The results of the present experiment expand
this literature, suggesting that physical exercise also reduces anxiety
associated with acute methamphetamine withdrawal and that physical
exercise may help alleviate the anxiety associated with methamphetamine
withdrawal in people.
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Diaz, L. R., Siontas, S., Mendoza, J., & Arvanitogiannis, A. (2012). High
levels of wheel running protect against behavioral sensitization to cocaine.
Behavioral Brain Research, 237, 82-85.
Lynch, W.J., Peterson, A.B., Sanchez, V., Abel, J. & Smith, M.A. (2013).
Exercise as a novel treatment for drug addiction: A neurobiological and
stage-dependent hypothesis. Neuroscience and Biobehavioral Reviews, 37,
1622-1644.
Salam, J. N., Fox, J. H., Detroy, E. M., Guignon, M. H., Wohl, D. F., &
Falls, W. A. (2009). Voluntary exercise in C57 mice is anxiolytic across
several measures of anxiety. Behavioural Brain Research, 197, 31-40.
Smith, M. A. & Lynch, W. J. (2011). Exercise as a potential treatment for
drug abuse: evidence from preclinical studies. Frontiers in Psychiatry, 2, 110.
Smith , M. A., & Witte, M. A. (2012). The effects of exercise on cocaine
self-administration, food-maintained responding, and locomotor activity in
female rats: Importance of the temporal relationship between physical
activity and initial drug exposure. Experimental Clinical
Psychopharmacology, 20, 437-446.
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Acknowledgements
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This research was supported Benson funds awarded to the Psychology
Department of Dickinson College by Abe and Grace Eva Wolf.
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Discussion
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Exercise
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V e h ic le
The present experiment examined if 6 weeks of voluntary access to an active running
wheel would attenuate the locomotor-activating effects to methamphetamine compared to
sedentary mice.
Given that physical exercise attenuated the locomotor-activating effects of cocaine in rats,
it was predicted that 6 weeks of voluntary access to a running wheel would attenuate the
locomotor-activating effects of methamphetamine in mice compared to sedentary mice.
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Anxiety
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V e r tic a l C o u n ts
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Results (Cont’d)
Rearing
V e r t ic a l C o u n t s
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To our knowledge, no research has examined if physical exercise attenuates the
locomotor-activating effects of methamphetamine in mice.
General Activity
V e r t ic a l C o u n t s
Previous research also found that 6 weeks of physical exercise attenuated the acute
locomotor- activating (Smith and Witte 2012) and sensitizing effects (Diaz, Siontas,
Mendoza & Arvanitogiannis 2012) of cocaine in rats compared to sedentary rats.
Dickinson College
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V e r tic a l C o u n ts
Preclinical studies have demonstrated that physical exercise can decrease the selfadministration of cocaine in rats, suggesting that physical exercise blunts the rewarding
properties of cocaine (Smith and Witte 2012).
Purpose/Prediction
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and Neuroscience
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Program ,
Running Wheel Activity (km)
Physical exercise has been proposed as a non-pharmacological treatment for drug
addiction (Smith & Lynch 2011).
D is t a n c e T r a v e le d ( c m )
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Department of
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Psychology
Results
D is t a n c e T r a v e le d ( c m )
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and Elisa
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Guma ,
Introduction
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Vouga
T im e in C e n t e r ( M in )
Anthony S.
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Rauhut , Alexandre
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