Transcript Weed, Pot, Reefer, Cannabis

Weed, Pot, Reefer,
Cannabis
Anybody want to get a pizza?
Introduction
Cannabis sativia
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May also be other species
One type is actually very low in THC and quite
useful for cloth, rope, paper, etc.
Speaking of THC, it is the active ingredient in
pot
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Delta-9-Tetrahdrocannabinol
Also Delta-8- Tetrahdrocannabinol
Delta 9 is the biggie though
Administration
You can:
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Eat it
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Cookies, brownies
Smoke it
Joints, bongs, onehits
 Hash and hah oil/weed oil
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Drink it
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Tea
‘Roll Your Own’
Recently some synthetics have been
developed
Don’t work as well as taking a hit off a Doobie
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synhexyl
nabilone
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Used in chemo treatment
dronabinol
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(Marinol)
A little History
Initially spread by the Scythians
Where do you think the word Assassin
comes from?
Chinese liked it, then they got the
munchies and ordered Chinese food…
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6000 years ago
Got to India
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Ganja and bhang
More History
In Europe and North America it was used for
rope, cloth etc, intoxicating effects were not
noticed for years.
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George Washington grew Hemp!
Gauthier’s ‘Le Club de Hachichins’
Big as a cash crop in the States
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(Still is )
1937 Marijuana Tax Act
1970 Became Illegal in the US, Canada.
Recent History
Medical Marijuana laws in US and
Canada
Feds actually growing weed in Flin Flon,
MB
Netherlands
Pot was almost legal last year!
Absorption, Distribution,
Etc…..
VERY lipid soluble
Very slowly absorbed when
administered orally
3x the dose than for smoked pot
 Much longer lasting high
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Smoking works way better
50% of THC goes to lungs
 Then to your brain
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Absorption etc…
Many of the compounds created during
burning are also psychoactive
Metabolized in liver mostly
Other places too
Lungs if smoked
 Intestines if eaten
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Metabolites are active
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Cannabidiol blocks metabolism of THC
Neuropharmacology
Radioactive Levonantradol
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(syntehtic cannabinoid)
Group in the next lab found a gene that
coded for a receptor site
The maps matched!
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Science is cool
So, where are the
receptors for THC?
Cortex
Hippocampus
Cerebellum
Basal ganglia
Spinal cord
Brainstem
Hypothalamus
Spleen!
Effects
Bloodshot eyes
Droopy eyes
The drys
The munchies
Increased heart rate
Reduction of pressure of fluid in eye!
More effects
Stops nausea
Anticonvulsant
Antibiotic
Sleep effects
Everything is way funny
Mood changes
Even more effects
Analgesic
Memory
Recall not recognition
 STM
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HP effect?
Attentional effects
Hey man, this weed has
lots of effects….
DON’T DRIVE A CAR
Biphasic effects on SMA
Taming effect
Timing effects
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Crystal (2003)
Reverse Tolerance?
Mild Withdrawal
You wanna get high?
Other species don’t do it
Titration
Usually smoked in groups
Most users are casual users
ritualistic
Bad stuff
Violence?
Makes crazy people go nuts
Freak outs
Gateway drug?
Reproductive effects?
Cancer, lung disease?
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Probably, but how much is smoked?