Transcript Nanocell - Chulabhorn Research Institute

Nanocell
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Intro of Drug Delivery System
What is nanocell
Ms. Chanokkamon
Marketing
Ethics
Mechanism
Ms. Soraya
Synthesis
Ms. Titima
In vivo In vitro
Dr. Panthee
Clinical trial
Dr. Bonduush
Summary
Nanocell:
Introduction, Marketing part
and Ethical issues
Ms Chanokkamon Cheawtada
Inter-U program AIT
Scope: Marketing and Ethics
• Drug delivery system
– General cancer
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Liver cancer treatment
Conventional drug for treat liver cancer
Problems of conventional drug
What is “nanocell”?
Advantage of nanocell
Compare cost-benefit between conventional drug
and nanocell
• Using Calculation for profit cost for developing
country (Ethics)
Drug delivery system for cancer
• Drug targeting of tumors
• Maximize drug potency
• Minimize systemic toxicity.
• Drug carrier
●Liposome
composed of one or more phospholipid bilayer
- e.g. liposome entrapped doxorubicin
●Bead
-e.g. drug-eluting microspheres/beads
(DEB) load with doxorubicin
●Prodrug
-e.g prodrug of cisplatin using dextran
(galactose unit)
Route of administation
Intravenous(iv)injection
Hepatic artery
Intravenous(iv)injection
Liver cancer treatment
Liver cancer
Localized unresectable
liver transplantation
Localized resectable
Systemic chemotherapy
Tumor embolization
Chemoembolization
Hormone therapy
Radiolabeled
Segmental resection Trisegmental resection
Recurrent
Conventional drugs
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Doxorubicin
IV injection
IV infusion
60-90 mg/m2- every 3 weeks
20-30 mg/m2/day - 3 days
every 3 to 4 weeks.
Dose depends upon which
regimen for cancer is being
Poor risk patient Reduce dosage
60-75 mg/m2
- every 3 weeks
From
http://asia.mims.com, http://www.rxmed.com
Conventional drugs
5-FU
IV injection
400 mg/m2
every 5 days
repeated every
4 weeks (28-day)
Oral
(capecitabine)
1250 mg/m2
twice daily 2 weeks
1 week rest
From
http://asia.mims.com, http://www.rxmed.com
Conventional drugs
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Cisplatin
IV infusion
50-100 mg/m2
every 3-4 week
15-20 mg/m2
daily for 5 days/week
for 3-4 week.
From
http://asia.mims.com, http://www.rxmed.com
Conventional drugs
Combretastatin
IV infusions
52 mg/m2
On day 1, 8, and 15.
courses repeat
every 28 days
From: http://www.jco.org
Problem of conventional drug
• Many side effect
- Drug effect on normal cell
e.g. acute nausea, vomiting, mucositis, anorexia, diarrhea,
• Less effective
- Drug cannot get into only liver but effect other organ
• Too complicate in treatment
- For treat liver cancer use series of drug for more effectiveness
• Series of drug
- take time for inject the drugs
- very painful because use large dose
• Expensive
• Drug resistance
From:http://www.medicalillustrator.com
Nanocell
• Nanocell is small particle between 10-1000nm.
- less than 200 nm.
- Can pass through tumor blood vessels
- The outer shell
anti-angiogenesis
- The inner core
chemotherapy drugs.
- A "stealth" surface
- avoid immune system
From:http://www.medicalillustrator.com
From:http://www.medicalillustrator.com, http://www.3d4medical.com
Advantages of Nanocell
• Directly to the target site ( liver cancer)
• Less side effect
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Not effect on normal cell
• Not complicate for treatment
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Inject only one time in one cycle of treatment
• More effective
• Less invasive
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less pianful
less injection time
• Economic price
• Easy to inject
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IV injection
Compare Cost-benefit
Drug
Dose
Duration (1cycle)
Price ($)
(6-8cycle)
Doxorubicin
- IV injection
- IV infusion
60-90 mg/m2
20-30 mg/m2
60-75 mg/m2
every 3 weeks
every day- 3 days every 3 to 4 weeks
every 3 weeks
8,501.76
8,501.76
7,084.80
400 mg/m2
1250 mg/m2
every day- 5 days repeated at 4 weeks
twice daily 2 weeks 1 week rest
11,808.00
11,336.22
50-100 mg/m2
15-20 mg/m2
every 3 to 4 week
daily 5 days/week for 3 to 4weeks
227.78
227.78
52or68mg/m2
On day 1, 8, and 15 every 28 days
38,304.04
100µl/kgBW
every 4 weeks
5-fu
- IV injection
- Oral
Cisplatin
- IV infusion
Combretastatin
- IV infusion
Nanocell
- IV infusion
4,546.89
http://www.etonbio.com, http://www.hon.ch/News/HSN/527057.html, http://www.biotrend.com, https://www.sigmaaldrich.com, http://www.rocheusa.com
Calculation profit
Sale
Capital
(US$)
Revenue
Sale price
(US$)
Profit
(1person )
(US$)
Retail
2,393.10
90%
4,546.89
2,153.79
Wholesale
2,393.10
50%
3,589.65
1,196.55
Ethical issues
• Liver cancer population
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high incidence in Asia.
• Almost countries in Asia are
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developing countries
• Almost developing countries have
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a large number of poor people
e.g. Thai GDP per capita income 2,221 US$
• “Nanocell for developing countries”
economic price
Nanocell for developing countries
11,868 persons
1995 – 1997
Sriamporn, et al(2002)
Summary
• So nanocell has been made for solving those
problems of the conventional drugs
• For its price, there are two target groups
which are:
- the developing countries such as Thailand,
Indonesia , it will be sold at whole sale
- the other countries at the retail.
Addition
Body surface area in m2 =
√ { height (cm) x weight (kg) }/3600
= 1.845 m2
Standard WHO
wieght
70 kg
Hight
1.75 metre
(from Norgan 1994)