Transcript P9498 - FLC dark template

Less Until None:
A Plan
for a World
without T1D
JDRF’s Vision for the Future
LESS
UNTIL
NONE
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Mission: Less Until None
LESS
Burden
UNTIL
LESS
Invasive
LESS
Complexity
LESS
Danger
NONE
LESS UNTIL NONE
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Therapies
Delivery of Continuous
Therapeutic Improvements
Side-Effects
Complications
Patient Burden
Cure
Glycemic Control
Safety
Normal Physiology
Restored
Better Safety, Fewer Side-Effects, Less Exposure to Complications
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Discovery
Research
$
Clinical
Development
$$
Regulatory
$$$
Delivery
to Patients
$$$$
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Discovery
Research
$
Clinical
Development
$$
Investment
Regulatory
$$$
Delivery
to Patients
$$$$
Investment
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Artificial Pancreas
Low Glucose
Suspend
Complications
Diabetic Eye
Disease
Artificial Pancreas
Treat-to-Range
Complications
Predictive
Diagnosis
Insulin Pumps
Infusion
Near Term
Prevention
Primary: Vaccine
Artificial Pancreas
Treat-to-Target
Encapsulation
Implantable Islets
Artificial Pancreas
Multihormone
Prevention
Secondary
Prevention
Medium Term
Regeneration
Complications
Comprehensive
Prevention Therapy
Control
Glucose
Responsive Insulin
Long Term
This timeline is based on clinical delivery goals of identified therapies and will be updated as progress is achieved
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Artificial Pancreas
Automated technologies to help
maintain better control of bloodglucose levels
Integrated smart technology to
automate routine elements of insulin
management
FDA released final guidance on
pathway for commercialization of
devices
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Glucose Responsive Insulin
(GRI)
Form of insulin that activated when
blood-glucose levels start to rise
Simplifies life for and improves overall
blood-glucose controls
JDRF competition underway to
accelerate progress on GRI
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Encapsulation
Easily implantable Beta cells or islets
surrounded by a protective
shield/capsule
Able to sense glucose levels and
produce insulin as needed
Hidden from the immune system to
sustain normal function
Eliminating the need for
immunosuppressive drug therapy
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Regeneration
Ability to create new insulin producing
cells destroyed by autoimmune attack
Creating abundant supply of Beta cells
through stem cells and regeneration
Immune therapy for suspected
“triggers” including viruses
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Secondary Prevention
Preserve beta cell function in these
newly diagnosed individuals
Approaches include:
Reducing inflammation
Boosting beta cell survival
Suppressing the autoimmune attack
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Primary Prevention
Prevent the autoimmune attack on
beta cells before it starts
Approaches include:
Viral vaccines
Beta Cell Autoantigen Vaccines
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Funding Scale
and Scope
R&D
Expertise
Industry
Influence
Government
Advocacy
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Funding Scale
and Scope
R&D
Expertise
Industry
Influence
Government
Advocacy
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Funding
Funding $$$
LESS=UNTIL
More
Less
T1D NONE
Funding
Funding
$$$ Funding
Funding
Funding
Funding
$$$
Funding
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Thank you!
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