Transcript Document

Be a Champion
2005 Workshop
Richard Higbee
Vice President
Global Marketing
Our Promise
• We promise you will leave with . . .
• A Clear Understanding of the Pharmanex
Vision and Strategy
• A Conviction That Pharmanex Products
Change Lives
• Key Message Points That Will Help You Build
Your Business
“Business Take-aways”
The Pharmanex Strategy
Our strategy is to leverage science in
order to create the most innovative
sponsoring products in the dietary
supplement and functional foods
industry.
Joseph Chang, Ph.D.
President of Pharmanex
Michael Chang, Ph.D.
Chief Scientific Advisor,
Pharmanex Fellow
First Pharmanex office
Homestead
A Victory for CholestinTM and
57 Million Americans
Cholestin, Good News for Better Health.
Here’s some very good news for the estimated 57 million
Americans who want a safe and 100% natural way to
promote and maintain healthy cholesterol levels* –
Cholestin is not a drug. A recent federal court ruling said
that Cholestin meets all criteria as a dietary supplement.
This distinction means that you can continue to enjoy
direct access to this remarkably effective product, giving
you an extremely strong weapon in the fight for better
health.
Research Confirms Cholestin Works.
Cholestin’s benefits have been supported by over 30 clinical studies,
all of which produced impressive results.
Most recently, a double-blind, placebo-controlled study
of Cholestin’s patented form of red yeast rice, was
conducted by the UCLA School of Medicine and
published by the American Journal of Clinical Nutrition.
The studies measured the effects on cholesterol levels before and after
supplementation with Cholestin. It was proven that Cholestin was
effective compared to the placebo group.
USA Today
Circa 1997
Pharmanex®
=
“Pharma-Next”
“Next Generation
Pharmaceutical”
I See a Future…
I See a Future…
• You as ambassadors of good health
I See a Future…
• You as ambassadors of good health
• The world knowing their antioxidant
score
Extraordinary Science…
Personalized
Revolutionized
Simplified
Extraordinary Science…
Personalized
Revolutionized
Simplified
Body Fat and Antioxidant Protection
35,000
Antioxidant Score
30,000
29,236
25,000
25,612
20,000
20,835
15,000
10,000
16,603
< 25
25-29
30-39
Body Mass Index
> 40
Breaking News:
Landmark Scanner Study
Skin Carotenoid Score = Antioxidant Protection
Extraordinary Science…
Personalized
Revolutionized
Simplified
Lighter – Smaller – Faster
S1
S2
Warm up time
30 min
5 min
Calibration time
17 min
4 min
Calibration steps
9 scans
3 scans
Weight of scanner
10 lbs
~5 lbs
Scan time
3 min
~2 min
70 – 75 °F
21 – 24 °C
50 – 95 °F
10 – 35 °C
Temperature range
Global Rollout
• China, Europe, US Markets
– February 2006
• Other markets soon after!
• Learn more in your regional meeting
I See a Future…
• A Winning Strategy
I See a Future…
• A Winning Strategy
• Simplicity
Extraordinary Science…
Personalized
Revolutionized
Simplified
Now is the time to Scan the
World!
10 Million People
by 2007
Michael’s Business Take-aways
• Original Pharmanex Slogan:
“Pharmaceutical companies improve health
with medicines, Pharmanex improves health
without medicine”
• Pharmanex is derived from “Pharma-next” or
“Next Generation Pharmaceutical”
Joe’s Business Take-aways
• 10M by 2007
• The scanner is the gold standard for overall
antioxidant protection
• We must “SCAN THE WORLD”
Major Accomplishments
• Global Product Rollout
–
–
–
–
•
•
•
•
BioPhotonic Scanner
TRA
Marine Omega
Estera
Stevie Award; NBJ Award
Product Certifications
China Manufacturing
Scanner “Oxidative Stress” Study
Science & Tradition
Mark R. Bartlett Ph.D.
Sr. Director Pharmanex
New Product Development
Fruit Phytonutrients
• At least 1,000 phytochemicals
identified with cell protective effects
• Very few (25) studied
• Fruits and vegetables – more than
meets the eye
• We don’t eat enough fruits and
vegetables
3 years ago…
Pharmanex began Searching
the World for Superfruits
– R&D evaluated hundreds of fruits for…
•
•
•
•
•
Extraordinary antioxidant power (Scanner)
Extraordinary nutritional contents
Quality of scientific efficacy data
Impeccable safety data
History of traditional folklore usage
Why the long search and
Why the long list?
Free Radicals Sources
• Environmental pollution (smog, ozone,
NO2)
• Radiation exposure:
– sunlight (UV-light), X-rays, etc.
• Smoking:
– 10,000,000,000,000,000 free
radicals/cigarette!
• Eating and Breathing:
mitochondria
metabolism in your
Mitochondria – The Energy
Furnaces of the body
Free Radicals
SOD
CAT
Pharmanex Research Centers
were involved…
1.Provo R&D Center
2.Shanghai R&D Center
3.Beijing R&D Center
years of searching
–Almost all failed Selection
criteria
–All but Four (g+3) very special
fruits
Gâc - “Fruit From Heaven”
• Indigenous to Southern Asia
Bangladesh, Burma, Cambodia,
China, India, Japan, Laos,
Malaysia, Philippines, Thailand, and
Vietnam
• Traditionally used internally
and externally
Topical: wound healing
Internally: eye health, and to
promote growth in children
Antioxidants in Gâc Pulp
• Extraordinarily rich in antioxidants, esp. lycopene,
beta-carotene, vitamin E
• Unique fatty acids → Lipocarotenes™
Fruit flesh
Pulp
(mesocarp)
(aril)
Seeds
Pharmanex Research Centers
3 Years of Searching and R&D
3 +1 Superfruits
1. Gâc fruit (Chinese Bitter Cucumber)
2. Chinese Lycium (Wolfberry)
3. Cili fruit
4. Siberian Pineapple (Seabuckthorn)
Gac Fruit Lycopene Content
2500
2227
2000
1500
70 x more
than tomatoes!
1000
500
0
31
Tomato
54
41
Watermelon
Guava
mcg/g wet weight
Ishida et al., J Agric Food Chem 52:274, 2004
Gac aril
Gac Fruit Beta-Carotene Content
800
718
700
600
500
10 x more
than carrots!
400
300
200
100
48
79
76
0
Spinach
Carrot
Sw.Potato
mcg/g wet weight
Ishida et al., J Agric Food Chem 52:274, 2004
Gac aril
Gâc
Fights
Vitamin A Deficiency
• …a Leading cause of blindness in the
world
• In So. Asia, Gâc discovered as potent
indigenous source of highly bioactive
provitamin A (b-carotene)
• 10 years of research by Dr. Le Vuong,
Univ. of California, Davis, Nutrition
Department
*Vuong LT et al., Am J Clin Nutr 2002;75:872-879.
Zeaxanthin in Chinese Lycium Fruit
1000
900
800
700
600
500
400
300
200
100
0
800
40 x more than
yellow corn!
18
Yellow Corn
mcg/g wet weight
Ch.Lycium
Vitamin C in Cili Fruit
2500
2500
2000
60 x more
than oranges!
1500
1000
500
0
30
Mandarin
mg/100g wet weight
45
Orange
71
Kiwi
Cili
™
Lipocarotenes
• Nature’s unique nutrient
delivery system in
• Gâc
– contain fatty acids (unique
among fruits)
– with carotenoids & vitamin E
pre-dissolved
– Gâc carotenes: 40 %
improved uptake*
*compared to beta-carotene powder. Vuong LT et al., Am J Clin Nutr
2002;75:872-879.
Vulnerable
to
Oxidation
Betacarotene
Lutein
Lycopene
Vitamin C
Internal Antioxidants
SOD
Catalase
SOD
CAT
Proprietary
• Patent pending, 100%-juice formula
• First juice with Gâc worldwide
• Pharmanex bought world supply of Gâc & Cili
(2004/2005 season)
will increase your scanner score!
– 4,000 – 7,000 units
@ 4 fl oz / day (8 weeks)
– 12,000 – 20,000 units
with LifePak®
Use
to take LifePak®!
EFFECT OF
AND OTHER JUICES ON
ANTIOXIDANT STATUS AS MEASURED
BY THE BIOPHOTONIC SCANNER
Purpose:
• To compare the effects of
,
XanGo™ and Tahitian Noni®
juices on antioxidant status
Study Design
• Subjects (N=34) were randomly assigned to
1 of 3 groups
• Subjects consumed 3 fluid oz twice per day,
with breakfast and with dinner for 8 weeks
• Comparable Daily Intakes
– 6 fl oz
(Maximum recommended intake)
– 6 fl oz Tahitian Noni® (6x’s Recommended dose)
– 6 fl oz XanGo™ (2x’s Recommended dose)
Increased Antioxidant Network
Scores ~9,500 in 8 Weeks
Antioxidant Network Score
50,000
1
2
3
4
5
6
7
8
9
10
11
40,000
30,000
20,000
10,000
Week 0
Week 8
Lipocarotenes™ in
are More Bioavailable
Antioxidant Score
10,000
8,000
6,000
4,000
2,000
0
Other
Carotenes
g3 Lipocarotenes
Increased Antioxidant Scores
4x’s More than XanGo™ or Noni
Antioxidant Score
10,000
Noni
XanGo™
#,
g3
#,
8,000
*
*
6,000
#,
*
4,000
*
2,000
0
Week 0
Week 2
*p<0.05 compared to wk 0
Week 4
Week 6
Week 8
#p<0.05 compared to other juices
Conclusions†:
•
dramatically increases antioxidant
scores.
• Lipocarotenes™ in g3 are 55% more
easily absorbed.
•
has 4x’s the antioxidant potential of
either XanGo™ or Tahitian Noni® Juice.
†Preliminary, unpublished data.
Thanks to
Angela Mastaloudis,
Ph.D. Associate Senior
Scientist
Mark’s Business Take-aways
• Scanner Developed:
was developed
because of the scanner
• SCS Certified: Guaranteed to Increase
•
•
•
•
Antioxidant Score
Superfruit: A fruit that contains unusually
high amounts of antioxidants
Lipocarotenes™: Natures unique delivery
system
First to Market: Proprietary, Patent Pending,
100% Juice, World supply of Gâc and Cili
Tahitian Noni® & XanGo™ Lose: Noni and
XanGo™ lose to g3 in scanner study
The Power of
Nanotechnology
Carsten R. Smidt, Ph.D., FACN
Vice President, Global R&D
What is Nanotechnology?
Example: Nano-Electronics
Nano-Switch
Nanotube Wires
A Matter of Size
100 nanometers
What is Nanotechnology?
1. A Matter of Size: 1 -100
nanometers
–
Most molecules are 1 to 100 nm in
size
2. Function at the Molecular Level
–
Nanotechnology is the science of
manipulating substances at the
molecular level
Pharmanex Nanotechnology
• To increase intestinal uptake of poorly
absorbed fat-soluble nutrients:
– Carotenoids (lycopene, alpha+betacarotenes, zeaxanthin, astaxanthin)
– Coenzyme Q10
Reasons for Poor Absorption
• Poor intestinal solubility
• Requires fat for
dissolution (e.g.,
Lipocarotenes)
• Aggregation into large
particles
– not easily digested and
absorbed
The Nanotechnology
Difference
Small nano-particles are easily dispersed and absorbed
™
NanoCoQ10
What is CoQ10?
• Coenzyme Q10, CoQ10, or ubiquinone
– fat-soluble, vitamin-like nutrient that
catalyzes energy production in cells*
– found in all cell membranes, nuclei and
mitochondria
– produced in the body—decreasing with
age
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
CoQ10 Health Benefits*
• Helps produce cellular energy, ATP
• Provides powerful protection against free
radical damage inside the cell (mitochondria)
• Strengthens heart muscle - supports
circulation
• Maintains existing normal blood pressure
• Skin health (anti-aging benefits)
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Regular CoQ10 Products
• Not easily absorbed into the body
• High dose needed to achieve
meaningful benefits
• NanoCoQ10™ uses molecular nanoencapsulation to significantly improve
absorption
CoQ10 Absorption by Human Intestinal Cells
pmol/mg protein
300.0
250.0
5-fold increase in absorption!*
200.0
30 mg ≈ 150 mg
150.0
100.0
50.0
0.0
Chewable A
Chewable B
Chewable C
CoQ10
powder
*Preliminary, laboratory data
Nano-CoQ10
powder
Summary
• Breakthrough nanotechnology
• Highly bioavailable CoQ10
• Heart protection*
• Helps produce cellular energy*
• Antioxidant protection*
• Use with Celltrex® CoQ10 Complete
• CoQ10 PowerPack
• More at the Nu Skin workshop!
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
Introducing
Highly Effective
Minerals
Red Wine
Polyphenols
New
Vitamin E
Nano-CoQ10
NanoNutrients
lifepak® nano: Nano-Antioxidants
Nano-CoQ10
Nano-Carotenoids?
lifepak®nano: Nano-Antioxidants
• New, broader-spectrum nanocarotenoid formula:
–
–
–
–
–
–
alpha-carotene
beta-carotene
lycopene
lutein
zeaxanthin (new): Eye health benefits*
astaxanthin (new): Immune response*
• plus LipoNutrients (proprietary process)
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
lifepak®nano: Omega-3 Lipids
• Delivers MarineOmega benefits:
– 600 mg EPA, 400 mg DHA
– Antarctic Krill oil
• Helps normalize omega 6/3 ratio in diet:
– helps maintain normal inflammatory response*
– promotes cardiovascular health*
– supports brain & nervous system*
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
lifepak®nano: Vitamin E Formula
• Gamma-tocopherol:
– synergistic antioxidant effects with alpha-tocopherol
(neutralizes different free radicals)*
– helps maintain normal inflammatory response*
• New vitamin E formula in lifepak® nano:
–
–
–
=
200 IU alpha-tocopherol (134 mg)
75 mg gamma-tocopherol
26 mg beta- and delta-tocopherols
235 mg total vitamin E (201 mg in LifePak® Prime)
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
lifepak® nano: Mineral Sources
• 600 mg Calcium, with new patented dicalcium
malate (soluble, organic Ca)
• 300 mg Magnesium, 100% amino acid chelate
• Plus 6 other bone nutrients: D, K, P, B, Si,
resveratrol*
• Advantage: More efficient absorption and better GI
tolerance than Ca and Mg in LifePak® Prime or
LifePak® Women
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
lifepak® nano: Red Wine Actives
• “1-2 glasses of red wine a day
keep the doctor away” (French Paradox)
• Cardiovascular benefits attributed to red
wine polyphenols:*
– Resveratrol
– Proanthocyanidins
– Quercetin
• lifepak® nano = 2 glasses red wine a day!
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
New Packet Design
• Unique 2-chamber design
– Separates soft-gels from hard shell capsules for
optimum stability
– New film with stronger protection and oxygen
barrier (as in LifePak® Japan)
Phytonutrients
Minerals
Vitamins
proprietary
CR-6 LipoNutrients
New Health Benefits*
• Helps maintain a healthy balance of pro- and antiinflammatory signals (prostaglandins) in the body
– Cardiovascular health (designed to lower C-reactive
protein)
– Joint health and mobility
• Expanded cell rejuvenation & anti-aging benefits
•
•
•
•
– CR6-LipoNutrients™, red wine benefits, 60+ antioxidants,
incl. nano-antioxidants
Complete bone support (8 nutrients)
New eye health benefits (lutein & zeaxanthin)
Improved gastro-intestinal tolerance
plus the benefits of LifePak® Prime
*Theses statements have not been evaluated by the Food and Drug Administration. This
product is not intended to diagnose, treat, cure, or prevent any disease.
®
lifepak
nano Study
60+ Antioxidants
Ongoing placebo-controlled clinical study
30000
28000
Raman Intensity
– 57 subjects
– 20 week study
– Better antioxidant
response than
LifePak®!
lifepak nano
26000
24000
LifePak
22000
Placebo
20000
18000
16000
14000
12000
10000
Day 0
Day 21
Day 42
Highly Effective
Minerals
Red Wine
Polyphenols
New
Vitamin E
Nano-CoQ10
NanoNutrients
For All Adults (age 18-121)
Cutting-Edge Science!
Broadest Health Benefits!
The New Dimension!
The Power of
Nanotechnology
Visit our PRODUCT SHOWCASE!
Win an iPod nano with lifepak® nano!
Purchase CoQ10 PowerPack and g3™!
Carsten’s Business Take-aways
• Nano Technology means increased
absorption
• CR6-LipoNutrients™ Technology is
proprietary and patent-pending
• Gentle to the stomach
• Guaranteed to increase antioxidant score
• Do You NANO?
Now is the Time
“The FUTURE is literally in your
hands and in the hands of the
people you scan”
Joe Chang
Be a Champion
2005 Workshop