Transcript THM IP Portfolio

The Sheba Medical Center
www.sheba.co.il
Sheba Medical Center at Tel Hashomer
Israel's National Medical Center
Sheba Medical Center - Facts and Figures

Comprises 120 departments and clinics, 1,800 beds,
6,800 healthcare professionals, including 900
doctors and 2,000 nurses.

Comprehensive care - an Acute Care Hospital with a
Rehabilitation Hospital, Maternity Hospital,
Children's Hospital, Medical Research Laboratory
Complex, and an Academic Campus.

1.5 million patient visits a year,
including 175,000 emergency visits,
90,000 inpatients and 2 million
medical tests each year.

Situated on a 150-acre campus.
Sheba Medical Center at Tel-Hashomer
Israel's National Medical Center
Research at Sheba

3200 researchers, technicians and lab workers

25% of Israeli medical research is performed at Sheba

600 clinical trials per year (200 industry-sponsored)

400 published articles per year

The main venue for human clinical trials conducted by the
Weizmann Institute, Tel Aviv and Bar-Ilan universities.

25 M$ /year income from grants, sponsored-research,
donations

81 biomedical patents, 37 licensed patents
Sheba Medical Center at Tel-Hashomer
Israel's National Medical Center
Our Research Facilities (Pre-Clinical)









75 laboratories spanning 35,000 m2 area
9 ISO-15189 approved laboratories
IVC-SPF small animal facility
Zebra fish facility
Genomic center equipped with last-generation genome
analyzers and microarray facilities
Advanced Microscopy Unit (multiphoton, microdissection,
electron and confocal microscopes)
Tissue bank with over 15,000 specimens and depositions from
over 400 new patients per year
Fully-automated MegaLab facility performing over 1000
different clinical tests
Surgery room for big animals with state-of-the-art equipment
Sheba Medical Center
Research and Development Powerhouse
Patent Committee
R & D Unit
TTO
Medical
Research
Centers
IP management &
Commercialization
Research & Licensing
Business
Partners
Commercial
Clinical
Sponsored
Research
Agreements
Research Funding
Grant coordinator
R&D collaborations
Research info
Business
Partners
Sheba Medical Center
Research Centers of Excellence
•
•
•
•
•
•
•
•
•
•
•
Research Center for Autoimmune Diseases
Research Center for Psychiatric and Dementia
Advanced Technology Center
Sheba Cancer Research Center
Regenerative Medicine Research Center
The Bert W. Strassburger Lipid Center
The Joseph Sagol Neuroscience Center
The Leviev Heart Center
The Multiple Sclerosis Research Center
Imaging Institute
Tissue Banking – Research Tools
Sheba Institutional Tissue Bank
The partner to accelerate Biomedical Research and Medical
Product Development through clinical & database resources
Lungs
Orthopedics
Thoracic
Thymus
Kidney
Urology
Bladder
Breast
Surgery
Prostate Adrenal
GI
Head and
Neck
Thyroid
Larynx
Melanoma
Brain
Sheba
Tissue
Bank
Nasal
Pharynx sinus
Hepato
-biliar
Gynecology
Ovary
Uterus
Children
All
‘Hemato’ solid
Bm & Bxtumors
Research & Development at Sheba
Collaboration with Research Institutes
Weizmann Institute of Science
Tel Aviv University
Bar Ilan University
MD Anderson, University of Texas
Cedars-Sinai Medical Center
Mayo Clinic
Cincinnati Children's Hospital Medical Center
The Cleveland Clinic Medical Center
Albert Einstein - Brazil
Sheba Medical Center
Commercial & Clinical Studies at Sheba
Period
Helsinki
Approval
Commercial
Research
Agreement
Research
Budget
(M IS)
2009
573
150
18.2
2010
572
188
38.4
2011
609
229
44.1
Sheba Medical Center
a Medical Research Powerhouse
Competitive Grant Sponsored Research at Sheba
Grant
Submission
Submission
number
Period
Grants
Awarded
% Awarded
Total Fund
awarded
(NIS/Million)
2008
88
29
33%
~ 13.2 M
2009
82
24
30%
~ 19.0 M
2010
124
33
27%
~ 22.5 M
Technology Transfer at Sheba
•
•
•
• Guided devices for GI tract
monitoring
• Non-invasive identification of
pathologic substances in amiotic
fluid
• Stem cell subretinal injector
Automatic classification of X-ray
images
BBB disruption analysis by MRI
On-line assessment of tissue
ablation
Other, 5
Imaging, 6
Medical
Devices, 11
Cell Therapy, 8
Biomarkers, 23
• Gene signatures for MS management /
personalized medicine
• Labeled somatostatin analogs
• Serum markers for bone maladies
Therapeutics,
20
• Cancer treatment by
recombinant Klotho,
CEACAM1, STIL
• Synthetic peptides for APS
•Bleeding treatment by
Fibrinogen
Sheba Medical Center
Technology Transfer Activities
Patent Commercialization
Activities





2002-7
2008
2009
2010
2011
Patent Application
(active) *
20
9
15
9
9 (+3)
Joined Patent
7
8
8
5
5
Research &
Licensing
Agreements
9
7
9
12
11 (+6)
Medical Device
Therapeutics & Drug Delivery
Biological Markers
Imaging
Stem Cells
20%
15%
25%
15%
25%
Total Patent Family –89
Total Commercial
agreements - 42
*15 patent applications were abundant
Research & Development at Sheba
Collaboration with the Industry
Ani-Biofilm compounds for Cleantech and medical applications
HUTCHISON WHAMPOA LIMITED
Novel Therapy for Blindness & Psoriasis
NIKKEN SOHONSHA Corporation
Production of antibodies to cellular proteins
SIGMA-ALDRICH ISRAEL Ltd
Antibodies to treat Melanoma
PONTIFAX and F. HOFFMANN-LA ROCHE Ltd.
Aortic Valve Implantation
VENTOR-MEDTRONIC
Convection-Enhanced Drug Delivery and MRI Monitoring
Schering-Plough
Apparatus for guiding medical devices in the GI
I. P. U Industrial, Israel
Research & Development at Sheba
Collaboration with the Industry
High-intensity focused ultrasound
InSightec
Antibodies to FRZ 7
Sigma
SiRNA to STIL gene – cancer treatment
Bioline
miRNA for Cancer Diagnostic
ROSETTA GENOMICS
Stem Cell Therapy for Renal Failure
Wolfson Clore Mayer VC
Novel Papilometer – Field View Analysis
ACCUTOME
Spinoff Companies
•
•
•
•
•
•
•
•
Nephrostem – cell therapy to treat renal failure
CCAM Medical – novel treatment for melanoma
MitralHeal - transapical mitral valve
Amniotix - spectral analysis of amniotic fluid
Radiologic - Automatic medical imaging analysis
Selpix - novel hair removing device
TopDyn - multiple sclerosis disease management
Orgenesis - cell therapy to treat diabetes
THM IP Portfolio
Monitoring Ablation of Tissues
Guiding Medical Devices in the Gastrointestinal Tract
Improved Electron Radiotherapy
Identification of Meconium in Amniotic Fluid
Novel diagnostic pill for GI applications
Objective Chromatic Perimetry Analysis Using Pupillometer
THM IP Portfolio
METHOD AND DEVICE FOR DETECTION OF ABNORMALITIES OF
THE GASTROINTESTINAL TRACT
Subretinal Injection Device
Methods and Devices Suitable for Imaging Blood-Containing
Tissue
Transapical Mitral Valve
Left Atrial Appendage Intra-atrial Clip
Colostomy Ileostomy Automatic Stapler Device
THM IP Portfolio
Klotho: Tumor suppressor of breast and pancreatic cancers
Targeting CEACAM1 for Cancer Therapy
Anti-Cancer Treatment - siRNA to STIL
Somatostatin Analogs – Platform for targeting Drugs
Cardiac Scar Rejuvenation by Chemical Peeling
Synthetic Peptide For Antiphospholipid Syndrome
Cancer Treatment with Exendin 4
Bleeding Treatment by Fibrinogen
Targeting Multiple Sclerosis - Si RNA to specific Target genes
Specific microRNAs (miRNA) selection for psoriasis treatment
Novel Target to treat Cancer Stem Cells
THM IP Portfolio
Transcriptional Signatures for Multiple Sclerosis Management
Gene Signatures for Brain Metastasis Prediction
Methods and Kits for Determining Predisposition to Warfarin Resistance
Human Serum markers for Bone Formation and Bone Maladies
Somatostatin analog for Cancer Diagnosis and Treatment
Trophoblast Markers for non-invasive Prenatal Diagnosis
Methyl-Tetrahydrofolate homocystein Methyl Transferase –
MTR as a marker for autoimmune diseases
Klotho Mutations in Breast Cancer
THM IP Portfolio
Stem Cell Therapy for Renal Failure
Cell Therapy for Diabetes
Stem Cells for Cardiac Applications
Recovery of all stem, progenitor and regenerative cells
Enrichment and Expansion of Human Stem Cells
from peripheral blood and umbilical vein cord blood
THM IP Portfolio
Automatic Analysis of X-rays by “Bag of Visual Words” Algorithm
Method and System for Monitoring Ablation of Tissues
BBB Disruption Assessment by MRI
THM IP Portfolio
Drug Discovery Platform for MS Drugs
Methods for Silencing Gene expression
In vivo Tool to Identify Novel Targets in Health and Disease useful for
Drug Screening based on A-I RNA editing
ERG transgenic mouse - a platform for preclinical studies of novel
therapeutics
Immunoassay for Monitoring Patient’s Response to Biological Drugs
Dynamic Contrast MRI for assessment of Blood Brain Barrier
Convection – Enhanced Drug Delivery
Small Scale Affinity Method for Biomarker Enrichment in Human Serum