Introduction to Biomedical Engineering
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Transcript Introduction to Biomedical Engineering
Biotransport in Biomedical
Engineering Course at UPRM
Rubén E. Díaz-Rivera, Ph.D.
Department of Mechanical Engineering
University of Puerto Rico – Mayagüez
Course Info
INME 5015/6065: Principles of Biomedical Engineering
3 credit hours, professional elective in ME
Advanced undergraduate/graduate level course
Popular with student in ME, EE, & ChemE
Typical enrollment: 15-20 students
Course Objectives
Describe several sub-areas of Biomedical Engineering and
the principles and applications that drive these sub-areas
Recognize the challenges and directions of the most
dynamic core areas in Biomedical Engineering
Apply mechanics concepts (e.g. transport phenomena) to
biological or medical problems
Course Textbook
Multiple textbooks
“Introduction to Biomedical Engineering”, J.
Enderle et al.
“Biomaterials: The intersection of Biology and
Material Science”, J.S. Temenoff & A.G. Mikos
“Transport Phenomena in Biological
Systems”, G.A. Truskey et al.
“Bioimpedance and Bioelectricity”, S.
Grimmes & Ø.G. Martinsen
“Introduction to Bioengineering”, S.A. Berger
et al.
“Fundamentals of Heat and Mass Transfer”, F.P.
Incropera et al.
“Thermodynamics: An Engineering Approach”,
Y.A. Çengel & M.A. Boles
Topics
History of biomedical engineering
FDA and ethical issues
Basic biology
Biomaterials
Biomechanics
Biofluid mechanics
Heat Transfer and Thermodynamics in Bio-systems
Mass Transfer in Bio-systems
Bioelectric Phenomena
Educational Strategy
Lectures
Homework
Plant tours
Zimmer, Boston Scientific,
Medtronic, Life Scan
Group Project
Educational Strategy
Group Project
The purpose of the group project is to select a product from a
recognized Biomedical Engineering company, compare it against
similar products on the market, and develop an improved
device based on the students engineering background and the
engineering fundamentals learned in class.
The project is divided into several tasks
Improvement of Drug Eluting Stents
Manufactured by
Cordis LLC, San
German, Puerto
Rico
Device Class
3
Product Code
NIQ
Submission Type
PMA
Objectives
Analyze the of mass
transport of the Drug
Eluting Stent manufactured
by Cordis (CYPHER)
Improve mass transport by
proposing polymeric
nanoparticles as an
alternative for drug release
M. Alvarez-Berríos, M. García-Jiménez, Chemical Engineering at UPRM
Improvement of Drug Eluting Stents
Release Rate (ng/s)
0.07
0.06
0.05
0.04
0.03
0.02
0.01
0
2
2.5
3
3.5
4
4.5
Radius (mm)
Release rate concentration as a function of radius
and length
Concentration profile for the drug in the blood a
function of time when using the stent (Co = 0.0226
g/cm3)
M. Alvarez-Berríos, M. García-Jiménez, Chemical Engineering at UPRM
Outcomes
Positive
This course puts the students
right outside their comfort zone,
which stimulates their creativity
The students get to tackle real life
problems (or close to it)
Students realize that they can
solve biological/medical related
problems w/ their engineering
background
Negative
Some students are not used to
have such freedom in selecting the
appropriate problem to solve and
end up missing the relevance of
the assignment
Most of the biotransport material
is covered late in the semester
Undergrads feel they don’t have
the appropriate tools (e.g.
COMSOL Multiphysics) to solve
some of the proposed problems
Thanks!