Transcript Introduction to Laboratoires Sérobiologiques Actives

Now it never hurts to
look a little younger.™
© Cognis Corporation 2001
• fatty acids
• fatty alcohols
• glycerine
• bulk surfactants
• ...
© Cognis Corporation 2001
• coatings & inks
• textile chemicals
• lubricants
• agricultural specialties
• ...
• natural-source vitamin E
• specialty surfactants
• emollients & emulsifiers
• actives
• ...
Actives from Care Chemicals
Generol® Phytosterols
Hydagen® Chitosan
Innovative Actives
Next-generation AHA Technology
Advanced Delivery Systems
© Cognis Corporation 2001
NeoStrata Company, Inc.
Drs. Van Scott and Yu published first
paper on skin benefits of AHAs in 1974.
Dr. Van Scott and Dr. Yu
Inventors of amphoteric hydroxy
complexes for low-irritation AHA actives.
NeoStrata holds over 100 patents on
AHA technology.
Strategic Alliance with Cognis
announced in 1999.
© Cognis Corporation 2001
NeoStrata’s headquarters
in Princeton, NJ.
Known Benefits of AHAs
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Exfoliation
Moisturization
Reduction of fine lines and wrinkles
Collagen synthesis
Firming
Skin whitening
Downside: stinging, irritation, ...
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the benefits of
AHAs with
significantly
reduced sting
and irritation.
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Amphoteric Hydroxy Complex
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Model of Controlled Release Concept
2.5
AHA
Concentration
2.0
1.5
Irritation Threshold
1.0
AHC
0.5
0.0
0
2
4
6
8
10
Time (arb. units)
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12
14
16
Dansyl Chloride Cell Turnover Study
Fluorescence Intensity (arb. units)
(10% lactic acid solution vs 14.7% AHCare™ L 65 solution)*
pH = 2.4
3.0
2.5
2.0
34% increase
in cell renewal
rate
1.5
1.0
AHA (Lactic)
AHC (Lactic/Arginine)
Control
0.5
0.0
0
2
4
6
8
Day
* the lactic acid concentration is identical in these two solutions
© Cognis Corporation 2001
10
12
14
Results for Facial Sting Study
AHC (high arginine) vs.
20% Lactic/NH4OH, neutralized to pH 3.5
Mean Sting Score
0.8
0.6
0.4
AHA (Lactic)
AHC (Lactic:Arginine mole ratio = 2.5:1)
0.2
0.0
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0
2
3
5
Time (min)
7
8
Results for Facial Sting Study
AHC (low arginine) vs.
10% Lactic/NH4OH, neutralized to pH 2.2
Mean Sting Score
1.5
1.0
0.5
AHA (Lactic)
AHC (Lactic:Arginine mole ratio = 20:1)
0.0
0
2
4
Time (min)
© Cognis Corporation 2001
6
8
Results for Facial Sting Study
AHC (high arginine) vs.
10% Glycolic/NH4OH, neutralized to pH 3.1
Mean Sting Score
1.5
1.0
0.5
AHA (Glycolic)
AHC (Glycolic:Arginine mole ratio = 2.5:1)
0.0
0
2
4
Time (min)
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6
8
Results for Facial Sting Study
AHC (low arginine) vs.
10% Glycolic/NH4OH, neutralized to pH 2.3
Mean Sting Score
2.0
1.5
1.0
0.5
0.0
AHA (Glycolic)
AHC (Glycolic:Arginine mole matio = 15:1)
0
2
4
Time (min)
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6
8
Cumulative Irritation Study
20% Glycolic Acid Solutions, pH 3.5
3.0
Mean Irritation Score
2.5
2.0
1.5
1.0
AHA (Glycolic)
AHC (Glycolic/Arginine mole ratio = 2.8:1)
0.5
0.0
0
2
4
6
8
Day
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12
14
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AHCare™ is Patented Technology
Key patents:
• R. J. Yu and E. J. Van Scott, “Amphoteric composition and
polymeric forms of alpha hydroxy acids and their therapeutic
use,” US Patent 5,091,171 (1992).
• R. J. Yu and E. J. Van Scott, “Molecular complex and controlrelease of hydroxy acids,” US Patent 5,681,853 (1997).
• plus 10 others, issued or pending.
Cognis has exclusively licensed these patents to
commercialize AHCare™ technology based on
glycolic and/or lactic acid.
© Cognis Corporation 2001
AHCare™ Products
Two standard products:
• AHCare™ G 60: patented complex of glycolic acid
and L-arginine, 74% total actives, glycolic/arginine
mole ratio = 15:1
• AHCare™ L 65: patented complex of lactic acid and
L-arginine, 75% total actives, lactic/arginine mole
ratio = 20:1
© Cognis Corporation 2001
Value Proposition for Skin Care Customers
When you buy AHCare™ skin care ingredients from Care
Chemicals you get:
• high efficacy with significantly reduced stinging and irritation
• freedom to practice under NeoStrata patents referenced above
on a worldwide basis.
• formulation support - including frame formula development to
match a market target
• claims substantiation support - including assistance with test
methods for both in vitro and in vivo methods.
© Cognis Corporation 2001
Dansyl Chloride Cell Turnover Study
Fluorescence Intensity (arb. units)
Anti-aging Cream containing 10% AHCare™ G 60
5
pH = 3.3
4
Control
10% AHCare G 60
3
2
21% increase
in cell renewal
rate
1
0
0
14
7
Day
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Summary
• High efficacy
• Significantly reduced stinging
and irritation
• Freedom to practice under
NeoStrata patents
• Extensive support
© Cognis Corporation 2001