Transcript Slide ()

Links between exceptional longevity and resistance to stress. (A) Skin-derived fibroblasts from long-lived mutant (red symbols, dw/dw, Snell dwarf) mice
are resistant to the lethal effects of hydrogen peroxide, H2O2. Each symbol is an individual mouse, and the Y-axis shows the amount of H2O2 needed to kill
50% of the cells. (Adapted from Murakami S, Salmon A, Miller RA. Multiplex stress resistance in cells from long-lived dwarf mice. FASEB J.
2003;17:1565–1566.) (B) Skin-derived fibroblasts from long-lived species are relatively resistant to lethal injury induced by H2O2. Each symbol represents
a different rodent or bat species with the indicated maximum lifespan. Species, left to right, are laboratory mouse, wild-caught mouse, rat, red squirrel,
white-footed mouse, deer mouse, fox squirrel, porcupine, beaver, and little brown bat. LD50 is the amount of hydrogen peroxide that kills 50% of the cells.
Source: Biology of Aging and Longevity, Hazzard's Geriatric Medicine and Gerontology, 7e
(Reproduced with permission from Harper JM, Salmon AB, Leiser SF, Galecki AT, Miller RA. Skin-derived fibroblasts from long-lived species are resistant
Halter stresses
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MA,2007;6:1–13.)
Ritchie C. Hazzard's
Geriatric
Medicine rodent
and Gerontology,
7e;
to some, butCitation:
not all, lethal
and toJG,
theStudenski
mitochondrial
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Aging Cell.
(C) Cells
from long-lived
species are
2017
Available
at:
http://mhmedical.com/
Accessed:
April
11,
2017
resistant to changes in oxidized proteins (“protein carbonyl” on Y-axis) induced by 1-h exposure to H2O2. Each symbol is a different species, with the
Copyright
© 2017
McGraw-Hill
Education. All
rights
reservedfrom Pickering AM, Lehr M, Kohler WJ, Han ML, Miller RA et al. Fibroblasts from
species’ lifespan
indicated
on the
X-axis. (Reproduced
with
permission
longer lived species of primates, rodents, bats, carnivores and birds resist protein damage. J Gerontol A Biol Sci Med. 2015;70:791–799.)