Transcript WP2 - Trimage

WP2
Corroboration of clinical evidences on mental
disorders and data mining
Karsten Heekeren
Department of Psychiatry, Psychotherapy and Psychosomatics
University of Zurich
WP2 Overview
Involved Units:
Participant no. /
Acronym
3 / FZJ
4 / JRB
5 / TUM
6 / UZH
Lead beneficiary
UZH
Participant legal name
Country
Forschungszentrum Juelich GmbH
JARA BRAIN, Department of Psychiatry, Psychotherapy
and Psychosomatics, RWTH, Aachen
Technische Universität Munich
Department of Psychiatry, Psychotherapy and
Psychosomatics, University of Zurich
Germany
Germany
Person months
47
Start month
1
Germany
Switzerland
End month
36
WP2 Implementation
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Task 2.1 Approval of the ethics committee and permission
according to the radiation protection (Strahlenschutzgenehmigung)
Task 2.2 Development of suitable paradigms for the new
PET/MR/EEG system
Task 2.3 Recruitment of the subjects and testing the new
paradigms on existing systems
Task 2.4 Analysis of the data and preparation of manuscripts
for publication
Task 2.5 Determination of optimal protocols for the new
Trimage scanner
WP2 Implementation





Task 2.1 Approval of the ethics committee and permission
according to the radiation protection (Strahlenschutzgenehmigung)
Task 2.2 Development of suitable paradigms for the new
PET/MR/EEG system
Task 2.3 Recruitment of the subjects and testing the new
paradigms on existing systems
Task 2.4 Analysis of the data and preparation of manuscripts
for publication
Task 2.5 Determination of optimal protocols for the new
Trimage scanner
WP2
Task 2.1 Approval of the ethics committee
Involved units
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JRB & TUM
2.1.1. Writing of the ethics application (start with the
beginning of the project in 12/2013) and submitting the
application to the ethics committee of the RWTH Aachen
University for [11C]-ABP688 PET/MR and of the Technical
University Munich for [18F]-Dopa PET/MR.
2.1.2 For PET examinations proposals will be sent to the
“Bundesamt für Strahlenschutz” Germany.
2.1.3 As soon as they are available, copies of ethical approval
and the permission according to the radiation protection will
be submitted to the European Commission and reported as a
deliverable. (It is assumed that the permits are granted at the
latest by the end of 2014.)
WP2
Task 2.1 Approval of the ethics committee
Involved units

JRB & TUM
2.1.3 As soon as they are available, copies of ethical approval
and the permission according to the radiation protection will
be submitted to the European Commission and reported as a
deliverable. (It is assumed that the permits are granted at the
latest by the end of 2014.)
 Munich  Approval of the Ethics Committee
 Jülich  A revised submission was required
 The decision of the “Bundesamt für Strahlenschutz” will
take some time (probably 6 months).
WP2 Task 2.2 Development of suitable
paradigms for the new PET/MR/EEG system
Involved units
FZJ, TUM-Med, UZH
Planned period of time for the development of the new
paradigms: 01/2014 to 06/2014.
 The paradigms are already available. However, there is still
a need for coordination between Jülich and Munich
regarding MRI.
 TUM PET/MR:
 PET tracer [18F]-Dopa
 Reward learning task fMRI, resting state
 Jülich PET/MR/EEG
 PET tracer [11C]-ABP688
 MMN, LDAEP, Startle PPI, resting state
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WP2 Schedule for the next six month
Involved units
JRB, FZJ, TUM-Med, UZH
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T-con in January 2015:
 Adjusting the MRI sequences between Jülich and Munich
(resting state, DTI).
 Focusing the inclusion criteria on schizophrenic patients with
prominent negative symptomatology
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We expect the ethical approval from Jülich and the permission
according to the radiation protection
WP2 Gantt Diagram
Task 2.5
Task 2.4
Task 2.3
Task 2.2
Task 2.1
1/12/13
Approval of the ethics committee and
permission according to the radiation
protection
30/11/14
30/11/15
29/11/16
28/2/14
1/12/13
1/1/14
Development of suitable paradigms for
30/6/14
the new PET/MR/EEG
Recruitment of the subjects and testing
1/7/14
30/9/15
of the new paradigms on existing systems
Analysis of the data and preparation of
1/7/15
31/3/16
manuskripts for publikation
Determination of otpimal protocols for
the new Trimage scanner
31/3/16
30/11/16
29/11/17
Thank you for your attention