Transcript Lysbilde 1
2015 The MoBa cohort Aim: To find causes of disease and factors involved in health related issues in a lifespan • A large population based pregnancy cohort • A family cohort (mother + father + child) • Long term follow-up Collaboration with 50 hospitals Hospitals with < 1000 births/year Hospitals with >1000 births/year Recruiting pregnant women and their partners midpregnancy Inclusion period 1998 - 2008 Norway 60,000 births/year Based on informed consent • Broad consent • Can be withdrawn at any point • Mother consented for herself and the child • Father separate consent • Child informed at 15 years • Child own consent at 18 years The MoBa cohort No No Mothers 95 000 Pregnancies Fathers 75 500 Twins Children 114 500 Triplets 113 000 1950 21 Data collection Ultrasound 18 W 22, 30 W Birth Blood Child Cord blood Blood Mother Blood Father Blood ½, 1½, 3, 5 Y 7Y Teeth 8Y 13, 14 Y Data collection in MoBa Pregnancy Mother, father, screening, health, lifestyle 17, 22, 30 w environmental exposure, diet (week 22) Postnatal 6 m Mother and child: health and lifestyle Q 18 month Mother and child: health and lifestyle Q 36 month Focused on child health and behaviour, Autism and ADHD Q 5 years Focused on language skills Q 7 years Focused on respiratory health, allergy and diet Q 8 years Mother and child's mental health, child development and language skills Planned data collection Fathers 13 year 14 year School 8y The fathers have only got a questionnaire at screening. Hopefully in 2015 a new questionnaire will be sent to all fathers. Main focus physical and mental health, relationship to child and mother of the child First questionnaire to the children. Main focus on mental health Questionnaire to the children regarded diet and nutrition Questionnaire to the teachers of MoBa children Biological samples MoBa: Top modern biobank – automated/manual 4.5 million samples stored • • • • EDTA whole blood and plasma (frozen -80o C) DNA extracted from whole blood (frozen -20o C) Urine (Mothers only) (frozen -20o C ) RNA: from cord blood (Tempus-tubes) Links with other registries National registers and databases Prescription registery National Patient Registry (NPR) Cancer registry Statistics Norway Sysvac Social Security Registery Disease specific registers. Established MoBa - MBR record (a sample of the MBR variables) MoBa – strengths of the study • The great number of participants • The family structure is the father-mother-child trio, with the possibility of studying twins and siblings • The wealth of information • The biological specimens • The unit of the datacollection is the pregnancy • The potential for genetic studies and elucidating gene-environmental interactions How representative is MoBa? • 40 % of all invited accepted • Socioeconomic gradient – Fewer <25 yrs, living alone, smokers, preterm deliveries, multiparous – More of supplement users, ”health-minded” • Questionnaires only in Norwegian – fewer immigrants • Decline in participation over time (<50 % for 8year questionnaire) Response rate, after dispatchment year 100 90 80 70 Q1, Pregnancy w 13-20 Q2, Pregnancy w 22 Q3, Pregnancy w 30 Q4, 6 months Q5, 18 months Q6, 36 months Q5y, 5 years Q7y, 7 years Q8y, 8 years QF, Pregnancy w 13-20 Response rate 60 50 40 30 20 10 0 1999 2000 2001 2002 2003 2004 2005 2006 Year 2007 2008 2009 2010 2011 2012 2013 Activities • Active research projects: 197 • Completed research projects: 125 • 14 projects have additional data collection (sub-cohorts) • 321 publications • 32 PhD projects completed Research areas • • • • • • • • • • • • • • • • • • • Infertility Diet in pregnancy Preeclampsia Preterm birth Hyperemesis Folic acid intake and consequences Eating disorders in pregnancy Medications in pregnancy Physical activity in pregnancy Pelvic girdle pain Urinary incontinence Smoking (maternal and paternal) Violence in pregnancy Childhood temperament Airway disease CHD and development Effect of early start in nursery ADHD Autism Pregnancy Child health Access to questionnaire data and biological material • Application – Application form – If required approval of formal bodies – Principal Investigator (PI) • PI must have a PhD or equivalent • PI must be affiliated with the sub-study institution • PI must assure that data and biological material are stored securely Application processing • Evaluation at the MoBa SMG meeting. – Within the aim of MoBa – Scientific standard of the sub-study – Conflict of interest regarding ongoing studies Charge for data access • Data files and questionnaire data – 3-5 publication (PhD/post Doc) NOK 100.000 – 1 publication NOK 30.000 – Data file updates NOK 10.000 • Projects assistance – Senior /research assistance NOK 815 • Cooperation fee – Long time projects, projects with separate data collection and extended access to data will be negotiated separately for each project • Ongoing evaluation of price strategy MoBa–funding • Governmental direct funding • National Institute of Public Health • Project funding – National Institutes of Health USA – Norwegian Research Council – EU Research framework programmes www.fhi.no/moba-en Questionnaire data Exposure data (and outcome data) • • • • • • • Somatic and mental health medication infections toxins diet / vitamins occupation/socioeconomic status life style/alcohol/smoking Information from blood and urine samples • • • • • • Genetic information environmental toxins infections dietary factors medication, drugs various other biomarkers MoBa film short version with English subtitles