Transcript Citrate reactions

Adverse Reactions
The complete absence of harmful effects, either immediate or delayed, when
UBI is used property, has allowed clinical investigators to use this procedure
over a period of twenty years and more on a single patient.
Citrate reactions.all typical citrate reactions, accompanied by headache, chill,
temporary fever of not more than 102.0 degrees F., and moderate calf muscle
spasm. This is less than 0.1%,
·
Photosensitization (Light) Reactions sulfa drugs being the worst offenders.
Iodide drugs can also be a problem, especially if given intravenously. Common
non-photosensitive medications (ones that are OK to use with UBI) include
penicillin, aspirin and other salicylates, broad-spectrum antibiotics, alkaloids,
glucose, saline, and whole blood and plasma. It is our experience that
psychotropic medications (pain pills, anxiety and depression pills) should be
used with caution as UBI may increase their effect upon the body’s chemistry.
·
Reactions due to death of bacteria (Herxheimer’s Reaction). This “die-off”
reaction is usually similar to “flu-like” symptoms of headache, achiness,
tiredness, and just “not feeling well” and usually lasts only several days.
·
Exacerbation reaction’s in chronic diseases. Dr. Miley reports that in
approximately 50% of individuals with bronchial asthma, nasal sinusitis and
chronic rheumatic disease (also in acute rheumatic disease), there appears for
the first four to five days following initial UBI an aggravation of the pre-existing
symptoms which is usually no more severe than any previous severe
exacerbation. This is especially true following the first application of UBI,
much less likely to occur after a second UBI, and rarely after third.
·
Possibility of producing shock.
Other reactions. A rare and mildly depressant effect
Effects of photon therapy
influencing the synthesis of prostaglandines
cracking of albumin molecules
immunomodulation
formation of antioxidative scavengers
influencing the oxyen-binding properties of the
red blood cells
metabolic effects
Influence on synthesis of prostaglandines
Cascade of arachidonic acid and inhibiting factors
phospholipase
steroids
cyclooxigenase
non-steroidal antiphlogistics
thromboxanesynthesis
prostacyclinesynthesis
thromboxane-A2
prostacycline
vasoconstriction
vasodilatation
Cracking of hydrogen-links in albumin molecules
biological effects:
- decreased plasma viscosity
- antiinflamatory activity
Immunomodulation caused by
ultraviolet blood irradiation
stimulation of the physiological
leucocytolysis
 Normal rate = 300000 per second
stimulation of unspecific
phagocytosis
increase of the humoral germicide
activity of the blood
increase of the rate of T4-helper
cells
Formation of antioxidative
scavengers
short living activated oxygen radicals act as a
stimulant on blood cells
blood cells start the production of antioxidative
enzymatic scavengers
somatic cells start the production of
antioxidative enzymatic scavengers after
retransfusion of the irradiated blood
Easier oxygen supply to body tissues
increased intracellular concentration of 2,3
diphosphoglycerates in the erythrocytes causes a
deviation to right at the oxigen binding curve
in blood
increased
O -capacity
2
“deviation to left”
normal
O -capacity
2
decreased
O -capacity
2
“deviation to right”
O capacity
Hb fully
saturated
(=1.00)
2
physical disolved O
2
O binding curve of the blood
2
Improvement of hemorheology and
hemodynamic properties
1. parameters of the rheology of the blood
 decrease of plasma viscosity
 improvement of the flexibility of erythrocytes
 decrease of the aggregation tendency of red
blood cells
 decrease of the aggregation tendency of
thrombocytes
 decrease of plasmatic fibrinogen level
 decrease of plasmatic lipid levels
2. Haemodynamic important parameters

dissolving of vasospastic phenomenons
The most important biological effects
of the ultraviolet blood irradiation
improvement of microcirculation
antiinflammatory effects
improvement of the performance of
the immunological system
protection against oxidative stress
improvement of different metabolic
activities
improvement of toxin clearance
through connecting tissue, liver and
kidneys
Physiological parameters influenced by
ultraviolet blood irradiation
Biophysical changes:
-improvement of electrophoretical
mobility of the erythrocytes
-increase of the electric charge of the
erythrocytes
-increase of the chemoluminescence
of the blood
- increase of the ATP-content of the
erythrocytes