Transcript CIDER

CIDER
Clinical Investigation Data Exploration Repository
CIDER
Clinical Investigation Data Exploration Repository
• Joint venture of BJC & WUSM
• Data repository to contain routine patient care
(inpatient and outpatient) data
• Advanced Query functionality through web
interface
• Restricted data access / Role Management
• Data Interface to external systems like CSMS
• Controlled Vocabulary support
Need for CIDER
• Clinical & Translational research goals
– Rapidly convert novel advances in basic science to
Patient care
– Get quick feedback on customized diagnostics and
therapeutics for further refinements back to the bench
• Need to analyze complex biomedical data
– Clinical Information
– Routine laboratory tests, imaging, biospecimens
– Molecular profiling and genome annotation
Need for CIDER – cont’d
• Data sets must be co-analyzed &
visualized to gain a comprehensive
understanding of underlying processes
occurring in multi-factorial diseases
• Easy access to this data for physicians,
clinician-scientists, and bench scientists
• Reduce barrier between basic science and
clinical research
Current challenges
• No easy way to access consolidated
patient data
• Privacy and confidentiality risks
• No seamless and regulated data access
• HIPAA regulations
How CIDER addresses
the challenges
• No easy way to access consolidated
patient data - Consolidated repository
• Privacy and confidentiality risks Secured data access based on user role
and project privileges
• No seamless and regulated data access Seamless & regulated data access
• HIPAA regulations - HIPAA training a must
for all CIDER users
Solution
CIDER
CIDER Data Repository
• Discrete Data from ClinDesk (IP Data)
o Demographics
o Encounters
o Labs
o Medications
o Vitals
o Allergies
o Microbiology
• Documents from ClinDesk, including Scanned Documents
(Hospital-based IP & OP Data)
o NLP (Natural Language Processing)
• AllScripts Data (WU Physician Offices OP Data)
• NextGen Data (BJC Medical Group Physician Offices OP Data)
• Diagnostic Images
• Other Sources (e.g.. MDL Discrete data)
CIDER Overall Timeline
CIDER Overall Timeline
Today
3/31/2009
v1.0
7/31/2009
v2.0
1/31/2010
v3.0
7/31/2010
v4.0
Maintenance
Releases
10/1/2008
1/1/2009
4/1/2009
7/1/2009
10/1/2009
1/1/2010
4/1/2010
7/1/2010
10/1/2010
1/1/2011
8/1/2008
3/31/2009
CIDER GUI Application
Most Inpatient Discrete
Data
Data Integration APIs
Vocabulary Interface
(Early Adopters)
1/31/2011
7/31/2009
CIDER GUI Application
All Inpatient Discrete
Data
Preliminary Outpatient
Data
Document Data
Rule Based Engine
(General Release)
1/31/2010
CIDER GUI Application
Final Patient Data
Prelim NLP
Prelim Image
(General Release)
7/31/2010
CIDER GUI Application
Final NLP
Final Image
(General Release)
Release-1 Modules
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Manage Users / Manage Projects
Query Module
Vocabulary Interface
Audit System
Data Delivery (conversion and interface)
Dashboard
APIs to external systems like CSMS
REFERENCES
CIDER
Data flow
CDR
Data
Repository
AllScripts
IRB
NextGen
CIDER
Imaging
Health Care World
Research World
CIDER-DATA TO CIDER-DOMAIN-MODEL
Via ETL Process
CIDER Database (DB2)
Data Source
DB2 – XML Database
XSDs
XSD - XML Schema Definition
Object Model – Graphical
Representation of Data Elements
and their Relationships
OBJECT MODEL
Via ETL Process
CIDER Database (DB2)
Data Source
DB2 – XML Database
XSD - XML Schema
Definition
XSDs
i-Query
Object Model – Graphical
Representation of Data Elements
and their Relationships
Generate Metadata
X-Query
OBJECT MODEL
What data to query?
Categories
CIDER Query Module
CIDER Workflow
CIDER Technology
• Web based GUI (Graphical User Interface)
which uses Java, Ajax, Flex and Web
services technologies
• Hierarchical and real-time data in XML
• Federated DB2 Databases on Linux
• Advanced Query capabilities (Graphical)
using XQuery / SQL-XML
• Multiple vocabulary support (SNOMED
CT, LOINC etc)
CIDER Architecture – cont’d