Transcript Document

"The Challenge of Innovation: Multi-disciplinary Collaboration,
Translation and Transitional Patient Care”
JoAnne Robbins, PhD, CCC-SLP, BRS-S
Professor
University of Wisconsin
School of Medicine and Public Health
March 18, 2013
"Breaking Barriers: Entering Into Interdisciplinary Collaborations”
Wisconsin Alumni Research Foundation (WARF)
Disclosures
Wisconsin Alumni Research Foundation (WARF)
Swallowing/Dining is a healthy part of life.
Swallowing
Moving food, liquid, secretions or
medications from the mouth to the
stomach, usually by a series of muscle
contractions causing pressure changes
in the aero-digestive tract
Dysphagia
A swallowing disorder characterized by
difficulty ...
18,000,000 adults with dysphagia in the U.S.
(AHRQ, 1999)
MILLIONS OF CHILDREN
Dysphagia is an element of Unhealthy Life
Multiple Anatomic and Physiologic Components
Vocal tract and GI tract both begin here:
Lips
Traditional View:
Lips to UES - vocal tract
UES to LES (stomach)
upper GI tract
Martin Donner, MD, Chairman Radiology Johns Hopkins
Multidisciplinary Team
TEAM:
Nutritionist
Nurse
Neurologist
Dentist/Hygienist
The ppt with the anatomy image (not X-ray - more like a Netter drawing) and different
Engineer
professionals who are members of the multi-d team "zoom in" on each side of image;
Health Service/Admin
again, Nicole borrowed for "Frick" presentation
Medical Physicist
SLP
Otolaryngologist
Radiologist
Gastroenterologist
Cardiothoracic
Surgeon
Collaboration
The team makes the dream But first, the dream IS the TEAM strategize, ...incentivize.... enthusivize(!?)
Greek enthousiasmos, from
enthousiazein to be inspired
High Jumping the Hurdles
Roles on grant submissions:
• Co-Investigators
• Collaborators
• Co-PIs
Share the costs:
• Effort and salary
• Travel and education
Apply to diverse funding agencies
reflecting specialty foci:
Local support:
UW Graduate School
UW Medical School
WARF-related:
IEDR,etc
NIH (gold standard): 1982 National Research Service Award,
1984 New Investigator Award, 1989 R01, 1994 second R01 …
NSF, USDA, VA
Smaller foundations/associations:
American Federation for Aging Research
Alzheimer's Association
American Cancer Society
Muscular Dystrophy Association
And MANY more
Share the burdens:
• Personnel (e.g. research administration)
• Space
• Resources
Institutional Support
Community Support
 Mentoring is an avenue to build
relationships for collaborations
 Many collaborations (prior to grant
writing) start with an idea that
spans the interest of colleagues
and develops over the literature
review/pilot data collection stage
to see if a grant application is
warranted
Joint lab meetings
Journal clubs
 Joint presentations at regional
and national meetings
Example
Sensorimotor Integration:
Nexus Between Dietary Modification and
Oropharyngeal Exercise
JoAnne Robbins, Ph.D., Professor, SMPH, University of Wisconsin-Madison
Rich Hartel, Ph.D., Professor, CALS, University of Wisconsin-Madison
Zata Vickers, Ph.D., Professor, University of Minnesota
Jackie Hind, M.S., University of Wisconsin-Madison
Georgia Malandraki, Ph.D., Assistant Professor, Columbia University*
American Speech-Language-Hearing Association (ASHA)
November 16, 2012
Atlanta, Georgia
*Post-doctoral fellow at UW-Madison
Share Positive Outcomes:
• Invitations to present the work
• Authorship – manuscripts
• Inventor - IP
What is desirable to
users?
INNOVATION
What is possible with
technology?
What is viable in the
marketplace?
Example
Madison Oral Strengthening Therapeutic (MOST) Device
• Requires pressure generation
• Multi-sensor custom fit mouthpiece
• Unit with adjustable target values and
knowledge of results to user
U.S. patent # 6702765 FDA Registered
Many different disciplines are
represented in our group
University of Wisconsin-Madison
Neil Binkley, M.D., Internal Medicine and Geriatrics
Rich Hartel, Ph.D., Food Science
Jackie Hind, M.S., Speech Pathology
Sterling Johnson, Ph.D., Clinical Neuropsychology
Nicole Pulia, Ph.D., Women’s Health
Scott Reeder, M.D., Radiology
JoAnne Robbins, Ph.D., Speech Pathology
Nasia Safdar, M.D., Infectious Diseases
Andrew Wacklawik, M.D., Neurology
Barbara Wolfe, Ph.D., Economist
University of Minnesota
Zata Vickers, Ph.D., Professor, Food Science and Nutrition
Columbia University
Georgia Malandraki, Ph.D., Assistant Professor, Speech and Language
Pathology
Johns Hopkins University
Ianessa Humbert, Ph.D., Assistant Professor, Speech Pathology
Patent = Protection of
Intellectual Property (IP)
Intellectual Property = property
(as an idea, invention, or
process) that derives from the
work of the mind or intellect
Host university or institution has office or
administrative unit to assist researchers in
protection of their IP and consider
commercialization options
Wisconsin Alumni Research
Foundation (WARF)
• Applications for patents/year = 365
• Accepted by WARF = 189 (56%)
• WARF has 1342 issued active US patents,
of which 617 (46%) have been licensed
Process
• Develop evidence
• Develop robust product
• Protect IP
- Patent
• Technology transfer
Market
- License to company in the field
Startup company (niche market)
Product
Concept
TECHNOLOGY TRANSFER
Process that moves research
discoveries from the lab or clinic to
marketplace by recruiting
commercial partners to invest in
developing (and marketing) new
products that benefit the public.
•
•
•
•
Start-up company
CEO Robert Carlson, MD
Licensed device(s) from WARF
Permits direct carryover from patient back
to lab
• Principal Investigator = Management Plan
and Exclusion to it (COI Committee)
Steps to Success
• Conceptualize
• Collaborate = build the team
• Funding partners = support
the team
• Innovate
• Develop
• Translate from lab to patient
• Gather evidence
• Industry partners
• Transitional care
It takes a Team…
Academics:
Kelsey Banaszynski, BS
Steven Barczi, MD
Jenny Christensen, BA
Elizabeth Donley, JD, MBA, MS
Richard Hartel, PhD
Angela Hewitt, MS
Jackie Hind, MS, CCC-SLP, BRS-S
Sterling Johnson, PhD
Amanda Joyce, MS
Junerose Juan, MA
Stephanie Kays, MS
Molly Knigge, MS, CCC-SLP
Georgia Malandraki, PhD
Shirley McCallum, MS, RD, CD, FADA
Heather Mendenhall, MS
Denise Ney, PhD
Mark Nicosia, PhD
Vivek Prabhakaran, MD, PhD
Scott Reeder, MD, PhD
Justin Sattin, MD
Dale Schoeller, PhD
Zata Vickers, PhD
WARF:
Carl Gulbrandsen, PhD, JD
Jeanine Burmania, MS
Beth Warner, PhD